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Gene Review

Ptv1  -  polytropic virus 1

Mus musculus

Synonyms: Ptv-1
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Disease relevance of Ptv1

  • Our results also confirmed a previous observation that during in vivo generation of recombinant leukemogenic viruses, the acquisition of polytropic virus-related sequences in the 3' portion of the p15E gene and the U3 region and in the 5' part of the gp70 gene can occur independently [1].
  • We have found that the final leukemogenic (MCF) virus is a recombinant of three different endogenous parents; an ecotropic virus, a polytropic virus that directs the gp70 region of env, and a xenotropic virus (identified as the inducible element Bxv-1) that directs the LTR [2].

High impact information on Ptv1

  • The profound amplification of polytropic MuLVs in coinfected mice may be facilitated by pseudotyping or, alternatively, by transactivation of the polytropic virus in the coinfected cells [3].
  • We report here the construction of a new packaging cell line, called MPAC, that packages defective retroviral vectors in viral particles with envelope proteins derived from a Moloney mink cell focus-inducing (MCF) polytropic virus [4].
  • Unique but similar polytropic virus-like genomes were present in each tumor isolate [5].
  • Rmc1, the cellular receptor for the polytropic class of murine retroviruses, determines the tissue tropism of the virus and therefore plays a critical role in the pathogenesis of polytropic virus-induced leukemia [6].

Anatomical context of Ptv1


  1. Thymic epithelial genotype influences the production of recombinant leukemogenic retroviruses in mice. Datta, S.K., Thomas, C.Y., Nicklas, J.A., Coffin, J.M. J. Virol. (1983) [Pubmed]
  2. Genetics of endogenous murine leukemia viruses. Coffin, J.M., Stoye, J.P., Frankel, W.N. Ann. N. Y. Acad. Sci. (1989) [Pubmed]
  3. In vivo interactions of ecotropic and polytropic murine leukemia viruses in mixed retrovirus infections. Evans, L.H., Lavignon, M., Peterson, K., Hasenkrug, K., Robertson, S., Malik, F., Virtaneva, K. J. Virol. (2006) [Pubmed]
  4. Gene transfer to human cells using retrovirus vectors produced by a new polytropic packaging cell line. Loiler, S.A., DiFronzo, N.L., Holland, C.A. J. Virol. (1997) [Pubmed]
  5. Genetic alterations of RNA leukemia viruses associated with the development of spontaneous thymic leukemia in AKR/J mice. Thomas, C.Y., Coffin, J.M. J. Virol. (1982) [Pubmed]
  6. An integrated somatic cell hybrid, YAC, and BAC map of the Rmc1 region of mouse chromosome 1. Hunter, K., Greenwood, J., Yang, Y.L., Cunningham, J.M., Birren, B., Housman, D. Genomics (1999) [Pubmed]
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