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Gene Review

Bxv1  -  B10 xenotropic virus 1

Mus musculus

Synonyms: Bxv-1, Xmv-43, Xmv43
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Disease relevance of Bxv1


High impact information on Bxv1


Biological context of Bxv1

  • Three of these substitutions are located immediately 3' of the enhancer core, and two form part of an E-box motif that is also found in the Bxv-1 sequence [3].
  • Recombinant murine leukemia viruses (MuLVs) from high-leukemia-incidence mouse strains typically acquire pathogenic U3 region sequences from the genome of the endogenous xenotropic virus, Bxv-1 [7].
  • Comparison of DNA sequences suggests that the pathogenicity of the CWD virus U3 region was related to a sequence motif that is shared with Bxv-1 and is recognized by the basic helix-loop-helix class of transcription factors [7].
  • The data imply that Bxv-1- and Bdv-1-dependent virus production require DNA synthesis and cell proliferation and, at least for Bxv-1, B-cell differentiation [8].

Anatomical context of Bxv1


Other interactions of Bxv1

  • Sxv is closely linked to, but distinct from Bxv-1, the major locus for induction of xenotropic murine leukemia viruses in laboratory mice [9].
  • Unlike that of Bxv-1, the restriction map of Nfxv-1 does not resemble that of any known infectious xenotropic virus including xenotropic viruses isolated from NFS mice [1].
  • After induction, hybrids with Bxv-1 produced only a transient burst of virus, whereas those with Akv-2 continued to produce virus for periods in excess of 3 months [10].
  • A single locus for inducibility of xenotropic murine leukemia virus was mapped to chromosome 1 close to, but possibly not allelic to, Bxv-1 [11].
  • We have found that the final leukemogenic (MCF) virus is a recombinant of three different endogenous parents; an ecotropic virus, a polytropic virus that directs the gp70 region of env, and a xenotropic virus (identified as the inducible element Bxv-1) that directs the LTR [12].

Analytical, diagnostic and therapeutic context of Bxv1


  1. Nonecotropic murine leukemia viruses in BALB/c and NFS/N mice: characterization of the BALB/c Bxv-1 provirus and the single NFS endogenous xenotrope. Hoggan, M.D., O'Neill, R.R., Kozak, C.A. J. Virol. (1986) [Pubmed]
  2. Origins of enhancer sequences of recombinant murine leukemia viruses from spontaneous B- and T-cell lymphomas of CWD mice. Massey, A.C., Lawrenz-Smith, S.C., Innes, D.J., Thomas, C.Y. J. Virol. (1994) [Pubmed]
  3. The E47 transcription factor binds to the enhancer sequences of recombinant murine leukemia viruses and influences enhancer function. Lawrenz-Smith, S.C., Thomas, C.Y. J. Virol. (1995) [Pubmed]
  4. Origin of pathogenic determinants of recombinant murine leukemia viruses: analysis of Bxv-1-related xenotropic viruses from CWD mice. Massey, A.C., Coppola, M.A., Thomas, C.Y. J. Virol. (1990) [Pubmed]
  5. Endogenous retrovirus expression in stimulated murine lymphocytes. Identification of a new locus controlling mitogen induction of a defective virus. Stoye, J.P., Moroni, C. J. Exp. Med. (1983) [Pubmed]
  6. Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains. Kozak, C.A., Rowe, W.P. J. Exp. Med. (1980) [Pubmed]
  7. Pathogenic determinants in the U3 region of recombinant murine leukemia viruses isolated from CWD and HRS/J mice. Lawrenz-Smith, S.C., Massey, A.C., Innes, D.J., Thomas, C.Y. J. Virol. (1994) [Pubmed]
  8. Proliferation and differentiation requirements for the induction of two retroviral loci during B-cell activation. Stoye, J.P., Moroni, C. J. Gen. Virol. (1985) [Pubmed]
  9. Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1. Kozak, C.A. J. Virol. (1985) [Pubmed]
  10. Differential expression of murine leukemia virus loci in chemically induced hybrid cells. Kozak, C.A. J. Virol. (1984) [Pubmed]
  11. Unique features of retrovirus expression in F/St mice. Morse, H.C., Kozak, C.A., Yetter, R.A., Hartley, J.W. J. Virol. (1982) [Pubmed]
  12. Genetics of endogenous murine leukemia viruses. Coffin, J.M., Stoye, J.P., Frankel, W.N. Ann. N. Y. Acad. Sci. (1989) [Pubmed]
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