Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

N - naked

Mus musculus

Tenenhouse, H.S. et al., Poland, A. et al., Scherer, F. et al., Xue, F. et al., Ma, C.H. et al., et al.

Ma, Zhang, Wang, Gao, Liu, Guo, Liu, Cao, Zhang, Sun,

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Disease relevance of N

In examination of mice with 7 other mutations affecting the integument, TCDD produced similar histologic skin changes in cryptothrix, nude, plucked, and atrichosis; a marginal squamous metaplasia of sebaceous glands in Repeated epilation, and had no effect in fur deficient and Naked mutants [1].

High impact information on N

BACKGROUND: Naked DNA and standard vectors have previously been used for gene delivery from implantable carrier matrices with great potential for gene therapeutic assistance of wound healing or tissue engineering [2].
METHODS: Naked plasmid DNA was injected under pressure into the cornea of mice [3].
Polyacrylamide-gel electrophoresis of this fraction prepared from the hair of both normal and Naked mice revealed that all protein bands present in the normal are also present in the Naked mice [4].
However, a densitometric scan of the gels at 280 nm showed that the soluble fibril fraction from Naked-mouse hair is deficient in several proteins which, on amino acid analysis, were found to contain 31% glycine and 10% tyrosine [4].
CONCLUSION: Naked endostatin plasmid intratumoral injection can get a similar gene transfection efficiency to liposome-DNA complex when used in situ [5].

Analytical, diagnostic and therapeutic context of N

CONCLUSIONS: Naked DNA injection and transfer by electroporation efficiently brings about HGF expression in vivo, which can attenuate acute liver injury [6].

References

Histologic changes produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the skin of mice carrying mutations that affect the integument. Poland, A., Knutson, J.C., Glover, E. J. Invest. Dermatol. (1984) [Pubmed]
Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo. Scherer, F., Schillinger, U., Putz, U., Stemberger, A., Plank, C. The journal of gene medicine. (2002) [Pubmed]
Rapid ocular angiogenic control via naked DNA delivery to cornea. Stechschulte, S.U., Joussen, A.M., von Recum, H.A., Poulaki, V., Moromizato, Y., Yuan, J., D'Amato, R.J., Kuo, C., Adamis, A.P. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
Loss of a homologous group of proteins in a dominantly inherited ectodermal malformation. Tenenhouse, H.S., Gold, R.J. Biochem. J. (1976) [Pubmed]
Human endostatin gene transfer, either naked or with liposome, has the same inhibitory effect on growth of mouse liver tumor cells in vivo. Ma, C.H., Zhang, Y., Wang, X.Y., Gao, L.F., Liu, H., Guo, C., Liu, S.X., Cao, Y.L., Zhang, L.N., Sun, W.S. World J. Gastroenterol. (2004) [Pubmed]
Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation. Xue, F., Takahara, T., Yata, Y., Minemura, M., Morioka, C.Y., Takahara, S., Yamato, E., Dono, K., Watanabe, A. Gut (2002) [Pubmed]

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