Disease relevance of Hair Removal

• We evaluated the efficacy of long-term cimetidine in treating hirsutism by monitoring four indices: subjective hair removal practice, grading of hair growth by the Lorenzo scale, photography, and hair weight measurement [1].
• Although severe combined immunodeficiency (SCID) mice lack mature T cells and B cells, IFN-gamma-dependent hair regrowth was induced in SCID mice by depilation, which caused alopecia in IFN-gamma(-/-) B6 mice [2].
• Serum levels of free and total testosterone and androstenedione were significantly elevated in PCO women, as were body weight, blood pressure, hair diameter and depilation frequency [3].

High impact information on Hair Removal

• We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning [4].
• The pupoid fetus (pf) and repeated epilation (Er) mutations of mice result in a failure of epidermal differentiation in homozygotes [5].
• Mice that received UV-A treatment combined with depilation had significantly improved lymphocyte responses to phytohemagglutinin and lipopolysaccharide and significantly decreased levels of anti-DNA antibodies compared with mice that received neither treatment [6].
• Analyses of integrin protein levels in extracts from full thickness skin, revealed increased levels of alpha3 and alpha9 integrins both prior to injury and after hair removal in syndecan-1(-/-) mice but no increase 2 days after dermabrasion [7].
• When anagen was induced by hair depilation at day 20 after birth, the vitamin D receptor null mice failed to initiate the hair cycle, whereas the vitamin D receptor null/human vitamin D receptor mice displayed the same pattern of anagen follicle formation as the wild-type mice [8].

Biological context of Hair Removal

• A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice [4].
• Before permanent use of peracetic acid for hand disinfection the possible hazards of depilation must be tested dermatologically [9].

Anatomical context of Hair Removal

• Tissue-specific regulation of junctional communication in the skin of mouse fetuses homozygous for the repeated epilation (Er) mutation [10].
• CONCLUSION: Selective photothermolysis of hair follicles with the normal-mode ruby laser produces a growth delay consistent with induction of prolonged telogen with apparently permanent hair removal in some cases [11].

Associations of Hair Removal with chemical compounds

• Mice were sensitized on the lower back skin with picryl chloride between 0 and 25 d, after anagen induction by depilation, and challenged on the earlobes with picryl chloride 5 d later [12].
• Adriamycin enhanced the epilation response to radiation, but only at or above threshold radiation doses [13].
• A range of drug doses of Adriamycin (ADR), Actinomycin-D (ACT-D), and Mitomycin-C (MMC) were given i.v. or i.p. to mice 1 day after a priming dose of radiation to elicit epilation response [14].
• Isotretinoin and wax epilation [15].
• Roaccutane and wax epilation: a cautionary tale [16].

Gene context of Hair Removal

• On days 8 and 12 after depilation, EP3 and EP4 mRNA were reexpressed in the dermal papilla cells and the outer root sheath cells, and the induction of COX-2 mRNA was also observed in the outer root sheath cells, the upper area of EP4 expression site [17].
• At 10 days after depilation, when the induced hair cycle was in mature anagen, the PKC alpha protein level was increased [18].
• The maximum epilation that appears at 8 days or at 8.5 weeks for proliferating and nonproliferating follicles was quantified using a subjective scale [14].
• CONCLUSIONS: Laser treatment appeared to reduce the severity of facial hair and time spent on hair removal as well as alleviating depression and anxiety in women with PCOS [19].
• Epidermal grafting after chemical epilation in the treatment of vitiligo [20].

Analytical, diagnostic and therapeutic context of Hair Removal

• The differentiation of repeated epilation (Er/Er) mouse mutant skin in organ culture and in grafts [21].
• C57 BL/6 mice were induced to enter into anagen by hair shaft depilation and a single intraperitoneal injection of cyclophosphamide (150 mg/kg) was given [22].

References