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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hair Removal

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Disease relevance of Hair Removal


High impact information on Hair Removal

  • We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning [4].
  • The pupoid fetus (pf) and repeated epilation (Er) mutations of mice result in a failure of epidermal differentiation in homozygotes [5].
  • Mice that received UV-A treatment combined with depilation had significantly improved lymphocyte responses to phytohemagglutinin and lipopolysaccharide and significantly decreased levels of anti-DNA antibodies compared with mice that received neither treatment [6].
  • Analyses of integrin protein levels in extracts from full thickness skin, revealed increased levels of alpha3 and alpha9 integrins both prior to injury and after hair removal in syndecan-1(-/-) mice but no increase 2 days after dermabrasion [7].
  • When anagen was induced by hair depilation at day 20 after birth, the vitamin D receptor null mice failed to initiate the hair cycle, whereas the vitamin D receptor null/human vitamin D receptor mice displayed the same pattern of anagen follicle formation as the wild-type mice [8].

Biological context of Hair Removal


Anatomical context of Hair Removal

  • Tissue-specific regulation of junctional communication in the skin of mouse fetuses homozygous for the repeated epilation (Er) mutation [10].
  • CONCLUSION: Selective photothermolysis of hair follicles with the normal-mode ruby laser produces a growth delay consistent with induction of prolonged telogen with apparently permanent hair removal in some cases [11].

Associations of Hair Removal with chemical compounds


Gene context of Hair Removal

  • On days 8 and 12 after depilation, EP3 and EP4 mRNA were reexpressed in the dermal papilla cells and the outer root sheath cells, and the induction of COX-2 mRNA was also observed in the outer root sheath cells, the upper area of EP4 expression site [17].
  • At 10 days after depilation, when the induced hair cycle was in mature anagen, the PKC alpha protein level was increased [18].
  • The maximum epilation that appears at 8 days or at 8.5 weeks for proliferating and nonproliferating follicles was quantified using a subjective scale [14].
  • CONCLUSIONS: Laser treatment appeared to reduce the severity of facial hair and time spent on hair removal as well as alleviating depression and anxiety in women with PCOS [19].
  • Epidermal grafting after chemical epilation in the treatment of vitiligo [20].

Analytical, diagnostic and therapeutic context of Hair Removal


  1. Treatment of hirsutism with cimetidine. Golditch, I.M., Price, V.H. Obstetrics and gynecology. (1990) [Pubmed]
  2. Cellular origin of IFN-gamma essential for hair cycle in normal skin. Yoneda, Y., Hirota, R., Tashiro, J., Okada, M., Sakurai, K., Lee, K., Ueda, K., Kubota, T., Yoshida, R. J. Interferon Cytokine Res. (2003) [Pubmed]
  3. Effects of a low-dose desogestrel-ethinylestradiol combination on hirsutism, androgens and sex hormone binding globulin in women with a polycystic ovary syndrome. Cullberg, G., Hamberger, L., Mattsson, L.A., Mobacken, H., Samsioe, G. Acta obstetricia et gynecologica Scandinavica. (1985) [Pubmed]
  4. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Herron, B.J., Liddell, R.A., Parker, A., Grant, S., Kinne, J., Fisher, J.K., Siracusa, L.D. Nat. Genet. (2005) [Pubmed]
  5. Abnormal expression and processing of keratins in pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice. Fisher, C., Jones, A., Roop, D.R. J. Cell Biol. (1987) [Pubmed]
  6. Ultraviolet-A light prolongs survival and improves immune function in (New Zealand black x New Zealand white)F1 hybrid mice. McGrath, H., Bak, E., Michalski, J.P. Arthritis Rheum. (1987) [Pubmed]
  7. Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. Stepp, M.A., Gibson, H.E., Gala, P.H., Iglesia, D.D., Pajoohesh-Ganji, A., Pal-Ghosh, S., Brown, M., Aquino, C., Schwartz, A.M., Goldberger, O., Hinkes, M.T., Bernfield, M. J. Cell. Sci. (2002) [Pubmed]
  8. Targeted expression of human vitamin d receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice. Kong, J., Li, X.J., Gavin, D., Jiang, Y., Li, Y.C. J. Invest. Dermatol. (2002) [Pubmed]
  9. Action of chronic peracetic acid (wofasteril) administration on the rabbit oral mucosa, vaginal mucosa, and skin. Müller, P., Raabe, G., Hörold, J., Juretzek, U. Experimental pathology. (1988) [Pubmed]
  10. Tissue-specific regulation of junctional communication in the skin of mouse fetuses homozygous for the repeated epilation (Er) mutation. Kam, E., Pitts, J.D. Development (1989) [Pubmed]
  11. Damage to hair follicles by normal-mode ruby laser pulses. Grossman, M.C., Dierickx, C., Farinelli, W., Flotte, T., Anderson, R.R. J. Am. Acad. Dermatol. (1996) [Pubmed]
  12. Hair cycle-dependent changes in skin immune functions: anagen-associated depression of sensitization for contact hypersensitivity in mice. Hoffman, U., Tokura, Y., Nishijima, T., Takigawa, M., Paus, R. J. Invest. Dermatol. (1996) [Pubmed]
  13. Adriamycin-induced recall of radiation pneumonitis and epilation in lung and hair follicles of mouse. Vegesna, V., Withers, H.R., McBride, W.H., Holly, F.E. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  14. Efficacy of i.v. or i.p. injected cytotoxic drugs on proliferating and non-proliferating hair follicles of the mouse. Vegesna, V., Withers, H.R. Int. J. Radiat. Oncol. Biol. Phys. (1991) [Pubmed]
  15. Isotretinoin and wax epilation. Egido Romo, M. Br. J. Dermatol. (1991) [Pubmed]
  16. Roaccutane and wax epilation: a cautionary tale. Woollons, A., Price, M.L. Br. J. Dermatol. (1997) [Pubmed]
  17. Expression of prostaglandin E(2) receptor subtypes in mouse hair follicles. Torii, E., Segi, E., Sugimoto, Y., Takahashi, K., Kabashima, K., Ikai, K., Ichikawa, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  18. Alteration of skin protein kinase C alpha protein and mRNA levels during induced mouse hair growth. Li, L.F., Chang, B.D., Roninson, I.B., Fiedler, V.C., Kumar, R. J. Dermatol. (1999) [Pubmed]
  19. A randomized controlled trial of laser treatment among hirsute women with polycystic ovary syndrome. Clayton, W.J., Lipton, M., Elford, J., Rustin, M., Sherr, L. Br. J. Dermatol. (2005) [Pubmed]
  20. Epidermal grafting after chemical epilation in the treatment of vitiligo. Kim, C.Y., Yoon, T.J., Kim, T.H. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2001) [Pubmed]
  21. The differentiation of repeated epilation (Er/Er) mouse mutant skin in organ culture and in grafts. Salaün, J., Salzgeber, B., Guénet, J.L. Anat. Embryol. (1986) [Pubmed]
  22. Anticancer drugs induce apoptosis in mouse hair follicles. Mori, O., Matsuo, K., Hashimoto, T. The Kurume medical journal. (2000) [Pubmed]
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