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Gene Review:

H30 - histocompatibility 30

Mus musculus

Synonyms: H-30

Scott, B.B. et al., Meruelo, D. et al., Yuhas, Y. et al., Péraldi-Roux, S. et al.

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Disease relevance of H30

The preinjection of sonicates of Shigella dysenteriae 60R or Escherichia coli H30 (producing Shiga toxin or Shiga-like toxin I, respectively) enhanced the response of mice to pentylenetetrazol within 6 h [1].

High impact information on H30

Although the locus coding for this antigen appears to be closely linked to the minor histocompatibility locus H-30 and to the locus coding for Ly 6.2, a chromosome assignment has not yet been made for my of these loci [2].
Na(+)-K(+) ATPase was apically detected by light and electron microscopy with a monoclonal antibody (Mab H30) in both cultured cells and sectioned tissues [3].
Molecular analysis of a panel of five anti-erythrocyte monoclonal antibodies (MoAb) derived from splenocytes of unimmunized NZB mice revealed that these autoantibodies all had functionally rearranged genes from the VH J558 family of immunoglobulin genes with closest homology to germline genes H10 and H30 [4].

References

An animal model for the study of neurotoxicity of bacterial products and application of the model to demonstrate that Shiga toxin and lipopolysaccharide cooperate in inducing neurologic disorders. Yuhas, Y., Weizman, A., Dinari, G., Ashkenazi, S. J. Infect. Dis. (1995) [Pubmed]
Definition of a new T lymphocyte cell surface antigen, Ly 11.2. Meruelo, D., Paolino, A., Flieger, N., Offer, M. J. Immunol. (1980) [Pubmed]
Choroidal ependymocytes in culture: expression of markers of polarity and function. Péraldi-Roux, S., Nguyen-Than Dao, B., Hirn, M., Gabrion, J. Int. J. Dev. Neurosci. (1990) [Pubmed]
Affinity maturation and isotype switch in clonally related anti-erythrocyte autoantibodies. Scott, B.B., Sadigh, S., Andrew, E.M., Maini, R.N., Mageed, R.A. Scand. J. Immunol. (1994) [Pubmed]

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