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MeSH Review

Mice, Inbred NZB

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Disease relevance of Mice, Inbred NZB


High impact information on Mice, Inbred NZB

  • To directly examine the contribution of these pleiotropic molecules, we created congenic NZB mice lacking the alpha-chain of IFN-alpha/betaR, the common receptor for the multiple IFN-alpha/beta species [6].
  • Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice [6].
  • This "Ly-1 B" subpopulation (identified and characterized by multiparameter FACS analyses) consists of relatively large, high IgM/low-IgD/low-Ly-1 lymphocytes that represent approximately 2% of the spleen cells in normal animals and, generally, 5-10% of spleen cells in NZB mice [7].
  • Studies with FACS-sorted cells show that the presence of Ly-1 on these IgM-secreting cells distinguishes them from the (Ly-1 negative) IgM-secreting "direct" plaque-forming cells generated in NZB mice after stimulation with sheep erythrocytes [7].
  • We have found that serum from some (NZB x CBA)F1 mice agglutinated erythrocytes from certain Coombs-positive NZB mice, often in extremely high titer, whereas other (CBA x NZB)F1 sera agglutinated erythrocytes from different individual NZB mice [8].

Biological context of Mice, Inbred NZB


Anatomical context of Mice, Inbred NZB


Associations of Mice, Inbred NZB with chemical compounds


Gene context of Mice, Inbred NZB

  • NZB mice that failed to respond to WEHI-3-derived G-CSF also failed to respond to MCGF [23].
  • IL-4 and IL-10 modulate autoimmune haemolytic anaemia in NZB mice [24].
  • In contrast, NZB mice fail to show significant expression of Ep-CAM even well into adulthood [25].
  • The production of such autoantibodies may interfere with B cell development in aging NZB mice by preventing IL-7-mediated proliferation [10].
  • To further examine the in vivo requirement for IL-10 in the development and expansion of malignant B-1 clones in NZB mice, we developed a strain of homozygous IL-10 knockout (KO) mice on an NZB background [26].

Analytical, diagnostic and therapeutic context of Mice, Inbred NZB

  • An immunofluorescence inhibition assay revealed the presence of autoantibodies with specificities of each NTA260 and NTA204 in the sera from NZB mice [27].


  1. Accumulation of cystine auxotrophic thymocytes accompanying type C viral leukemogenesis in the mouse. Livingston, D.M., Ferguson, C., Gollogly, R., Lazarus, H. Cell (1976) [Pubmed]
  2. Analysis of lymphocyte proteins from New Zealand black mice by two-dimensional gel electrophoresis. Lal, R.B., Monos, D.S., Chused, T.M., Cooper, H.L. J. Immunol. (1985) [Pubmed]
  3. Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis. Kikuchi, S., Fossati-Jimack, L., Moll, T., Amano, H., Amano, E., Ida, A., Ibnou-Zekri, N., Laporte, C., Santiago-Raber, M.L., Rozzo, S.J., Kotzin, B.L., Izui, S. J. Immunol. (2005) [Pubmed]
  4. Studies on J-chain biosynthesis in tumours producing immunoglobulins in NZB mice. Kaji, H. Biochem. J. (1976) [Pubmed]
  5. Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains. Bailey, N.C., Bona, A., Dikman, S., Bonilla, F., Alt, F.W., Bona, C. Eur. J. Immunol. (1991) [Pubmed]
  6. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. Santiago-Raber, M.L., Baccala, R., Haraldsson, K.M., Choubey, D., Stewart, T.A., Kono, D.H., Theofilopoulos, A.N. J. Exp. Med. (2003) [Pubmed]
  7. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. Hayakawa, K., Hardy, R.R., Parks, D.R., Herzenberg, L.A. J. Exp. Med. (1983) [Pubmed]
  8. Anti-idiotypic antibodies to the Coombs antibody in NZB F1 mice. Cohen, P.L., Eisenberg, R.A. J. Exp. Med. (1982) [Pubmed]
  9. T cell abnormalities in NZB mice occur independently of autoantibody production. Taurog, J.D., Raveche, E.S., Smathers, P.A., Glimcher, L.H., Huston, D.P., Hansen, C.T., Steinberg, A.D. J. Exp. Med. (1981) [Pubmed]
  10. Autoantibodies inhibit interleukin-7-mediated proliferation and are associated with the age-dependent loss of pre-B cells in autoimmune New Zealand Black Mice. Merchant, M.S., Garvy, B.A., Riley, R.L. Blood (1996) [Pubmed]
  11. Modulation of autoimmunity in NZB mice by cyclophosphamide-induced, nonspecific suppressor cells. Greeley, E.H., Segre, M., Segre, D. J. Immunol. (1985) [Pubmed]
  12. Variations in expression of xenotropic murine leukemia virus genomes in lymphoid tissues of NZB mice. Morse, H.C., Chused, T.M., Sharrow, S.O., Hartley, J.W. J. Immunol. (1979) [Pubmed]
  13. Naturally occurring antibody response to DNA is associated with the response to retroviral gp70 in autoimmune New Zealand mice. Shirai, T., Ohta, K., Kohno, A., Furukawa, F., Yoshida, H., Maruyama, N., Hirose, S. Arthritis Rheum. (1986) [Pubmed]
  14. Detection of neuropeptide Y and its mRNA in megakaryocytes: enhanced levels in certain autoimmune mice. Ericsson, A., Schalling, M., McIntyre, K.R., Lundberg, J.M., Larhammar, D., Seroogy, K., Hökfelt, T., Persson, H. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  15. Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. Kaushik, A., Schulze, D.H., Bonilla, F.A., Bona, C., Kelsoe, G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  16. Peptides containing a dominant T-cell epitope from red cell band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia. Shen, C.R., Youssef, A.R., Devine, A., Bowie, L., Hall, A.M., Wraith, D.C., Elson, C.J., Barker, R.N. Blood (2003) [Pubmed]
  17. Reduced susceptibility to Fas-mediated apoptosis in B-1 cells. Masuda, K., Wang, J., Watanabe, T. Eur. J. Immunol. (1997) [Pubmed]
  18. Demonstration of islet cell surface antibodies in sera of New Zealand black mice and inhibitory effect on insulin release. Yamada, K., Hanafusa, T., Fujino-Kurihara, H., Miyazaki, A., Nakajima, H., Miyagawa, J., Kono, N., Nonaka, K., Tarui, S. Diabetes (1986) [Pubmed]
  19. Genetic studies in NZB mice. IV. The effect of sex hormones on the spontaneous production of anti-T cell autoantibodies. Raveche, E.S., Tjio, J.H., Steinberg, A.D. Arthritis Rheum. (1980) [Pubmed]
  20. Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice. McCoy, K.L., Baker, P.J., Malek, T.R., Chused, T.M. J. Immunol. (1985) [Pubmed]
  21. Studies of the effects of sex hormones on autosomal and X-linked genetic control of induced and spontaneous antibody production. Raveche, E.S., Tjio, J.H., Boegel, W., Steinberg, A.D. Arthritis Rheum. (1979) [Pubmed]
  22. Nutritional factors and autoimmunity. IV. Dietary vitamin A deprivation induces a selective increase in IgM autoantibodies and hypergammaglobulinemia in New Zealand Black mice. Gershwin, M.E., Lentz, D.R., Beach, R.S., Hurley, L.S. J. Immunol. (1984) [Pubmed]
  23. Long-term in vitro culture of murine mast cells. III. Discrimination of mast cells growth factor and granulocyte-CSF. Yung, Y.P., Moore, M.A. J. Immunol. (1982) [Pubmed]
  24. IL-4 and IL-10 modulate autoimmune haemolytic anaemia in NZB mice. Youssef, A.R., Shen, C.R., Lin, C.L., Barker, R.N., Elson, C.J. Clin. Exp. Immunol. (2005) [Pubmed]
  25. Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. Taguchi, N., Hashimoto, Y., Naiki, M., Farr, A.G., Boyd, R.L., Ansari, A.A., Shultz, L.D., Kotzin, B.L., Dorshkind, K., Ikehara, S., Gershwin, M.E. J. Autoimmun. (1999) [Pubmed]
  26. Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma. Czarneski, J., Lin, Y.C., Chong, S., McCarthy, B., Fernandes, H., Parker, G., Mansour, A., Huppi, K., Marti, G.E., Raveche, E. Leukemia (2004) [Pubmed]
  27. Two distinct monoclonal natural thymocytotoxic autoantibodies from New Zealand black mouse. Ohgaki, M., Ueda, G., Shiota, J., Nishimura, H., Hirose, S., Sato, H., Shirai, T. Clin. Immunol. Immunopathol. (1989) [Pubmed]
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