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SLC27A4  -  solute carrier family 27 (fatty acid...

Homo sapiens

Synonyms: ACSVL4, FATP-4, FATP4, Fatty acid transport protein 4, IPS, ...
 
 
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Disease relevance of SLC27A4

  • RESULTS: In acquired obesity FATP4 expression was up-regulated independently of genetic background (DeltaFATP4 versus DeltaBMI; r=0.50, p=0.04; DeltaFATP4 versus Deltabody fat; r=0.59, p=0.01) [1].
 

High impact information on SLC27A4

  • New data reveal that insulin may regulate this process in part by promoting membrane trafficking of intracellular fatty acid transporters FATP1 and FATP4 to the plasma membrane [2].
  • However, this is dependent on the enzymatic activity of FATP4, catalyzing the esterification of fatty acids with CoA [3].
  • Here, we show that FATP4 is in fact localized to the endoplasmic reticulum and not the plasma membrane as reported previously [3].
  • CONCLUSIONS/INTERPRETATION: These findings indicate that expression of specific adipose tissue fatty-acid-handling proteins is related to obesity and insulin resistance, and that, in particular, FATP4 plays a role in acquired obesity [1].
  • However, the mRNA expression of FATP-1 and FATP-4 in placenta was correlated with DHA in both maternal plasma and placental phospholipids, although only FATP-4 expression was significantly correlated with DHA in cord blood phospholipids [4].
 

Biological context of SLC27A4

 

Associations of SLC27A4 with chemical compounds

  • A three-dimensional model of the FATP4 protein based on structural and functional similarity with adenylate-forming enzymes revealed that the variable residue 209 is exposed in a region potentially involved in protein-protein interactions [5].

References

  1. Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance. Gertow, K., Pietiläinen, K.H., Yki-Järvinen, H., Kaprio, J., Rissanen, A., Eriksson, P., Hamsten, A., Fisher, R.M. Diabetologia (2004) [Pubmed]
  2. Fat targets for insulin signaling. Czech, M.P. Mol. Cell (2002) [Pubmed]
  3. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. Milger, K., Herrmann, T., Becker, C., Gotthardt, D., Zickwolf, J., Ehehalt, R., Watkins, P.A., Stremmel, W., F??llekrug, J. J. Cell. Sci. (2006) [Pubmed]
  4. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Larqu??, E., Krauss-Etschmann, S., Campoy, C., Hartl, D., Linde, J., Klingler, M., Demmelmair, H., Ca??o, A., Gil, A., Bondy, B., Koletzko, B. Am. J. Clin. Nutr. (2006) [Pubmed]
  5. Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. Gertow, K., Bellanda, M., Eriksson, P., Boquist, S., Hamsten, A., Sunnerhagen, M., Fisher, R.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
 
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