The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC27A4  -  solute carrier family 27 (fatty acid...

Homo sapiens

Synonyms: ACSVL4, FATP-4, FATP4, Fatty acid transport protein 4, IPS, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC27A4

  • RESULTS: In acquired obesity FATP4 expression was up-regulated independently of genetic background (DeltaFATP4 versus DeltaBMI; r=0.50, p=0.04; DeltaFATP4 versus Deltabody fat; r=0.59, p=0.01) [1].

High impact information on SLC27A4

  • New data reveal that insulin may regulate this process in part by promoting membrane trafficking of intracellular fatty acid transporters FATP1 and FATP4 to the plasma membrane [2].
  • However, this is dependent on the enzymatic activity of FATP4, catalyzing the esterification of fatty acids with CoA [3].
  • Here, we show that FATP4 is in fact localized to the endoplasmic reticulum and not the plasma membrane as reported previously [3].
  • CONCLUSIONS/INTERPRETATION: These findings indicate that expression of specific adipose tissue fatty-acid-handling proteins is related to obesity and insulin resistance, and that, in particular, FATP4 plays a role in acquired obesity [1].
  • However, the mRNA expression of FATP-1 and FATP-4 in placenta was correlated with DHA in both maternal plasma and placental phospholipids, although only FATP-4 expression was significantly correlated with DHA in cord blood phospholipids [4].

Biological context of SLC27A4


Associations of SLC27A4 with chemical compounds

  • A three-dimensional model of the FATP4 protein based on structural and functional similarity with adenylate-forming enzymes revealed that the variable residue 209 is exposed in a region potentially involved in protein-protein interactions [5].


  1. Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance. Gertow, K., Pietiläinen, K.H., Yki-Järvinen, H., Kaprio, J., Rissanen, A., Eriksson, P., Hamsten, A., Fisher, R.M. Diabetologia (2004) [Pubmed]
  2. Fat targets for insulin signaling. Czech, M.P. Mol. Cell (2002) [Pubmed]
  3. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. Milger, K., Herrmann, T., Becker, C., Gotthardt, D., Zickwolf, J., Ehehalt, R., Watkins, P.A., Stremmel, W., F??llekrug, J. J. Cell. Sci. (2006) [Pubmed]
  4. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Larqu??, E., Krauss-Etschmann, S., Campoy, C., Hartl, D., Linde, J., Klingler, M., Demmelmair, H., Ca??o, A., Gil, A., Bondy, B., Koletzko, B. Am. J. Clin. Nutr. (2006) [Pubmed]
  5. Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. Gertow, K., Bellanda, M., Eriksson, P., Boquist, S., Hamsten, A., Sunnerhagen, M., Fisher, R.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
WikiGenes - Universities