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Gene Review

SLC27A1  -  solute carrier family 27 (fatty acid...

Homo sapiens

Synonyms: ACSVL5, FATP, FATP-1, FATP1, FLJ00336, ...
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Disease relevance of SLC27A1


High impact information on SLC27A1

  • Here, we show that fatty acid transport protein (FATP)1 is expressed on the plasma membrane of BAT and is upregulated in response to cold stimuli, concomitant with an increase in the rate of fatty acid uptake [6].
  • Stimulation of fatty uptake by isoproterenol required both protein kinase A and mitogen-activated kinase signaling and is completely dependent on FATP1 expression, as small-hairpin RNA-mediated knock down of FATP1 abrogated the effect [6].
  • Fatty Acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue [6].
  • Similarly, FATP1 is expressed by the BAT-derived cell line HIB-1B upon differentiation, and both fatty acid uptake and FATP1 protein levels are rapidly elevated following isoproterenol stimulation [6].
  • As a consequence, FATP1 knockout (KO) animals display smaller lipid droplets in BAT and fail to defend their core body temperature at 4 degrees C, despite elevated serum free fatty acid levels [6].

Chemical compound and disease context of SLC27A1


Biological context of SLC27A1


Anatomical context of SLC27A1


Associations of SLC27A1 with chemical compounds

  • FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells [16].
  • Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency) [17].
  • Toward that end, we determined the activities of key enzymes in the pathway of TG synthesis, the rates of uptake of fatty acids by adipocytes, mRNA and protein levels of the fatty acid-transporting proteins FAT/CD36 and FATP, and mRNA and protein levels of PPARgamma in omental fat of AAW and CAW [18].
  • It is proposed that FATP indirectly enhance LCFA uptake by activating VLCFA to their CoA esters, which are required to maintain the typical structure of lipid rafts in cellular membranes [19].
  • The effects of LPS on FATP and FAT mRNA levels in liver were observed as early as 4 h after administration and were maximal by 16 h [1].

Other interactions of SLC27A1

  • Biosynthesis of lipids was investigated in growing 293 cells stably expressing fatty acid (FA) transport protein 1 (FATP1), a bifunctional polypeptide with FA transport as well as fatty acyl-CoA synthetase activity [16].
  • CONCLUSIONS: Correlation of the mRNA expression of the membrane placental proteins FATP-1 and especially of FATP-4 with maternal and cord DHA leads us to conclude that these lipid carriers are involved in placental transfer of long-chain polyunsaturated fatty acids [15].
  • Released into circulation as non-esterified fatty acids by lipoprotein lipase, those are taken up by adipose tissue via specific plasma fatty acid transporters (CD36, FATP, FABPpm) and used for triacylglycerol synthesis [20].
  • TNF and IL-1 mimicked the effect of LPS on FATP and FAT mRNA levels in both liver and adipose tissue [1].
  • On the basis of fine mapping of a quantitative trait loci region of BTA3 for milk fat content, an examination of the comparative map between cattle and human indicates that the annexin 9 protein gene (ANXA9) and the fatty acid transport protein type 3 gene (SLC27A3) are two strong candidate genes [21].


  1. Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines. Memon, R.A., Feingold, K.R., Moser, A.H., Fuller, J., Grunfeld, C. Am. J. Physiol. (1998) [Pubmed]
  2. Fatty acid transport by the lipophilic bacterium Nocardia asteroides. Calmes, R., Deal, S.J. J. Bacteriol. (1976) [Pubmed]
  3. Metabolic aspects of the calorigenic effect of thyroid hormone in mammals. Sestoft, L. Clin. Endocrinol. (Oxf) (1980) [Pubmed]
  4. Energy translocation across cell membranes and membrane models. Pownall, H.J., Hamilton, J.A. Acta Physiol. Scand. (2003) [Pubmed]
  5. Fatty acid transport in multiple carboxylase deficiency fibroblasts. Packman, S., Whitney, S. J. Inherit. Metab. Dis. (1990) [Pubmed]
  6. Fatty Acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue. Wu, Q., Kazantzis, M., Doege, H., Ortegon, A.M., Tsang, B., Falcon, A., Stahl, A. Diabetes (2006) [Pubmed]
  7. Arrhythmias and conduction defects as presenting symptoms of fatty acid oxidation disorders in children. Bonnet, D., Martin, D., Pascale De Lonlay, n.u.l.l., Villain, E., Jouvet, P., Rabier, D., Brivet, M., Saudubray, J.M. Circulation (1999) [Pubmed]
  8. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. Martin, G., Nemoto, M., Gelman, L., Geffroy, S., Najib, J., Fruchart, J.C., Roevens, P., de Martinville, B., Deeb, S., Auwerx, J. Genomics (2000) [Pubmed]
  9. A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. Gertow, K., Skoglund-Andersson, C., Eriksson, P., Boquist, S., Orth-Gomér, K., Schenck-Gustafsson, K., Hamsten, A., Fisher, R.M. Atherosclerosis (2003) [Pubmed]
  10. Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Heather, L.C., Cole, M.A., Lygate, C.A., Evans, R.D., Stuckey, D.J., Murray, A.J., Neubauer, S., Clarke, K. Cardiovasc. Res. (2006) [Pubmed]
  11. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Fruchart, J.C., Duriez, P., Staels, B. Curr. Opin. Lipidol. (1999) [Pubmed]
  12. Fatty acid transporters (FABPpm, FAT, FATP) in human muscle. Bonen, A., Miskovic, D., Kiens, B. Canadian journal of applied physiology = Revue canadienne de physiologie appliquée. (1999) [Pubmed]
  13. Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophy. Hajri, T., Ibrahimi, A., Coburn, C.T., Knapp, F.F., Kurtz, T., Pravenec, M., Abumrad, N.A. J. Biol. Chem. (2001) [Pubmed]
  14. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. Milger, K., Herrmann, T., Becker, C., Gotthardt, D., Zickwolf, J., Ehehalt, R., Watkins, P.A., Stremmel, W., F??llekrug, J. J. Cell. Sci. (2006) [Pubmed]
  15. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Larqu??, E., Krauss-Etschmann, S., Campoy, C., Hartl, D., Linde, J., Klingler, M., Demmelmair, H., Ca??o, A., Gil, A., Bondy, B., Koletzko, B. Am. J. Clin. Nutr. (2006) [Pubmed]
  16. FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells. Hatch, G.M., Smith, A.J., Xu, F.Y., Hall, A.M., Bernlohr, D.A. J. Lipid Res. (2002) [Pubmed]
  17. Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). Fukuchi, K., Nozaki, S., Yoshizumi, T., Hasegawa, S., Uehara, T., Nakagawa, T., Kobayashi, T., Tomiyama, Y., Yamashita, S., Matsuzawa, Y., Nishimura, T. J. Nucl. Med. (1999) [Pubmed]
  18. Differences in transport of fatty acids and expression of fatty acid transporting proteins in adipose tissue of obese black and white women. Bower, J.F., Davis, J.M., Hao, E., Barakat, H.A. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  19. New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae. Pohl, J., Ring, A., Ehehalt, R., Herrmann, T., Stremmel, W. The Proceedings of the Nutrition Society. (2004) [Pubmed]
  20. Metabolism of lipids in human white adipocyte. Large, V., Peroni, O., Letexier, D., Ray, H., Beylot, M. Diabetes Metab. (2004) [Pubmed]
  21. Isolation, mapping and identification of SNPs for four genes (ACP6, CGN, ANXA9, SLC27A3) from a bovine QTL region on BTA3. Calvo, J.H., Martínez-Royo, A., Silveri, L., Floriot, S., Eggen, A., Marcos-Carcavilla, A., Serrano, M. Cytogenet. Genome Res. (2006) [Pubmed]
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