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Gene Review:

RBPMS - RNA binding protein with multiple splicing

Homo sapiens

Synonyms: HERMES, Heart and RRM expressed sequence, Hermes, RBP-MS, RNA-binding protein with multiple splicing

Shimamoto, A. et al., Sun, Y. et al., Sahasrabudhe, P.V. et al.

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High impact information on RBPMS

A unique gene, RBP-MS, spanning over 230 kb in the human chromosome 8p11-12 near the Werner syndrome gene locus is described [1].
Northern blot analysis showed that the RBP-MS gene was expressed strongly in the heart, prostate, intestine, and ovary, and poorly in the skeletal muscle, spleen, thymus, brain, and peripheral leukocytes [1].
The regions of RBP-MS which are homologous to the template protein snRNP U1A were constrained by "homology distance constraints," while the conformation of the non-homologous regions were defined only by a potential energy function [2].
Moreover, RBPMS fails to enhance the transcriptional activity of Smad2 and Smad3 that lack the C-terminal phosphorylation sites [3].
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS [3].

Physical interactions of RBPMS

The presence of TGF-beta increases the binding of RBPMS with these Smad proteins [3].

References

A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. Shimamoto, A., Kitao, S., Ichikawa, K., Suzuki, N., Yamabe, Y., Imamura, O., Tokutake, Y., Satoh, M., Matsumoto, T., Kuromitsu, J., Kataoka, H., Sugawara, K., Sugawara, M., Sugimoto, M., Goto, M., Furuichi, Y. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Homology modeling of an RNP domain from a human RNA-binding protein: Homology-constrained energy optimization provides a criterion for distinguishing potential sequence alignments. Sahasrabudhe, P.V., Tejero, R., Kitao, S., Furuichi, Y., Montelione, G.T. Proteins (1998) [Pubmed]
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. Sun, Y., Ding, L., Zhang, H., Han, J., Yang, X., Yan, J., Zhu, Y., Li, J., Song, H., Ye, Q. Nucleic Acids Res. (2006) [Pubmed]

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rbpms	Xenopus (Silurana) tropicalis

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