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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

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Gene Review: 

TRIM31  -  tripartite motif containing 31

Homo sapiens

Synonyms: C6orf13, E3 ubiquitin-protein ligase TRIM31, HCG1, HCGI, RNF, ...
 
 
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Disease relevance of TRIM31

  • Crude percents of local failure with or without other sites (LF), distant metastases including regional nodal failure (DM/RNF), or other first events (second primaries/death without recurrence) were estimated for each treatment group [1].
  • We assessed the prevalence of carriage of methicillin-resistant Staphylococcus aureus (MRSA) in anterior nares and stools, and of third-generation cephalosporin resistant enterobacteriaceae and non-fermenting gram-negative bacilli (RE/RNF) in stools of 748 hospitalized long-stay cirrhotic patients [2].
  • The patient also suffered from cutaneous and visceral Kaposi's sarcoma (KS), which had been treated with high- dose HCG1 and well recognized chemotherapeutic protocols [3].
 

High impact information on TRIM31

  • Supporting this, 1) the binding of norfenfluramine (NF) analogs lacking an S-(+) alpha-methyl group (RNF and alpha-desmethyl-NF) was less sensitive to the V2.53L mutation, and 2) a V2.53A mutation decreased SNF affinity 190-fold, but decreased RNF and alpha-desmethyl-NF affinities only 16- and 45-fold, respectively [4].
  • Recurrences were reported as the 5-year crude sites of first failure, and were divided into breast recurrences (LR), regional nodal failure (RNF, defined as isolated axillary, supraclavicular, or internal mammary recurrence), and distant metastases (DM) [5].
  • Green fluorescent protein (GFP) plasmid or red nuclear fluorescent protein (RNFP) plasmid were sequestered in NPs [6].
  • MRSA and RE/RNF carriers had received prior antibiotic therapy to a greater extent than non-carriers (P < 0.001) and MRSA carriers had received prior norfloxacin prophylaxis to a greater extent than the two other groups (P < 0.02) [2].
  • This study was performed in co-operation with the Registration Network of Family Practices (RNFP) of the University of Limburg [7].
 

Biological context of TRIM31

References

  1. Timing of radiotherapy and chemotherapy following breast-conserving surgery for patients with node-positive breast cancer. International Breast Cancer Study Group. Wallgren, A., Bernier, J., Gelber, R.D., Goldhirsch, A., Roncadin, M., Joseph, D., Castiglione-Gertsch, M. Int. J. Radiat. Oncol. Biol. Phys. (1996) [Pubmed]
  2. Epidemiology of hospital-acquired infections in cirrhotic patients: effect of carriage of methicillin-resistant Staphylococcus aureus and influence of previous antibiotic therapy and norfloxacin prophylaxis. Campillo, B., Dupeyron, C., Richardet, J.P. Epidemiol. Infect. (2001) [Pubmed]
  3. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect. Harris, P.J. AIDS patient care and STDs. (1996) [Pubmed]
  4. Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor. Setola, V., Dukat, M., Glennon, R.A., Roth, B.L. Mol. Pharmacol. (2005) [Pubmed]
  5. The significance of extracapsular extension of axillary lymph node metastases in early-stage breast cancer. Hetelekidis, S., Schnitt, S.J., Silver, B., Manola, J., Bornstein, B.A., Nixon, A.J., Recht, A., Gelman, R., Harris, J.R., Connolly, J.L. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  6. Nanoparticles for gene delivery to retinal pigment epithelial cells. Bejjani, R.A., BenEzra, D., Cohen, H., Rieger, J., Andrieu, C., Jeanny, J.C., Gollomb, G., Behar-Cohen, F.F. Mol. Vis. (2005) [Pubmed]
  7. Completeness of cancer registration in Limburg, The Netherlands. Schouten, L.J., Höppener, P., van den Brandt, P.A., Knottnerus, J.A., Jager, J.J. International journal of epidemiology. (1993) [Pubmed]
  8. Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growth-inhibitory genes. Dokmanovic, M., Chang, B.D., Fang, J., Roninson, I.B. Cancer Biol. Ther. (2002) [Pubmed]
  9. The initial RNF research survey: rehabilitation nursing research interests of ARN members. Hoeman, S.P., Dayhoff, N.E., Thompson, T.C. Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses. (1993) [Pubmed]
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