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Gene Review:

Cebpe - CCAAT/enhancer binding protein (C/EBP),...

Mus musculus

Synonyms: C/EBP epsilon, C/EBPe, C/EBPepsilon, CCAAT/enhancer-binding protein epsilon, CRP1, ...

Nagaev, I. et al., Lilly, B. et al., Chumakov, A.M. et al.

Chumakov, Kubota, Walter, Koeffler,

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High impact information on Cebpe

The CCAAT enhancer binding protein epsilon (C/EBP-epsilon) transcription factor is expressed predominantly in granulocytes [1].
To further our understanding of smooth muscle gene regulation, we characterized the cis-regulatory elements of the murine cysteine-rich protein 1 gene (CRP1/Csrp1) [2].
Mouse Cebpe and Retnlg were predictably expressed in macrophages, whereas Retn was abundant in adipocytes [3].
Thus, the myeloid-restricted nature of CEBPE precludes the expression of RETN in human adipocytes which, however, are targeted by this innate immune-derived proinflammatory cytokine [3].
Real-time RT-PCR analysis demonstrated lack of both the transcriptional factor CEBPE and RETN expression in adipose and muscle cells [3].

Biological context of Cebpe

We examined the human CEBPE-regulatory pathway by unbiased reference and custom gene expression assays [3].

References

Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family. Chumakov, A.M., Kubota, T., Walter, S., Koeffler, H.P. Oncogene (2004) [Pubmed]
Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells. Lilly, B., Olson, E.N., Beckerle, M.C. Dev. Biol. (2001) [Pubmed]
Human Resistin Is a Systemic Immune-Derived Proinflammatory Cytokine Targeting both Leukocytes and Adipocytes. Nagaev, I., Bokarewa, M., Tarkowski, A., Smith, U. PLoS ONE (2006) [Pubmed]

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