The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RETN  -  resistin

Homo sapiens

Synonyms: ADSF, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RETN


Psychiatry related information on RETN


High impact information on RETN


Chemical compound and disease context of RETN


Biological context of RETN


Anatomical context of RETN


Associations of RETN with chemical compounds


Regulatory relationships of RETN


Other interactions of RETN


Analytical, diagnostic and therapeutic context of RETN


  1. Resistin, an adipokine with potent proinflammatory properties. Bokarewa, M., Nagaev, I., Dahlberg, L., Smith, U., Tarkowski, A. J. Immunol. (2005) [Pubmed]
  2. Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells. Shen, Y.H., Zhang, L., Gan, Y., Wang, X., Wang, J., LeMaire, S.A., Coselli, J.S., Wang, X.L. J. Biol. Chem. (2006) [Pubmed]
  3. Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha. Seo, J.B., Noh, M.J., Yoo, E.J., Park, S.Y., Park, J., Lee, I.K., Park, S.D., Kim, J.B. Mol. Endocrinol. (2003) [Pubmed]
  4. Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. Youn, B.S., Yu, K.Y., Park, H.J., Lee, N.S., Min, S.S., Youn, M.Y., Cho, Y.M., Park, Y.J., Kim, S.Y., Lee, H.K., Park, K.S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  5. Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone. Kamin, D., Hadigan, C., Lehrke, M., Mazza, S., Lazar, M.A., Grinspoon, S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  6. Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. Housova, J., Anderlova, K., Krizová, J., Haluzikova, D., Kremen, J., Kumstyrová, T., Papezová, H., Haluzik, M. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  7. Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. Housová, J., Wilczek, H., Haluzík, M.M., Kremen, J., Krízová, J., Haluzík, M. Physiological research / Academia Scientiarum Bohemoslovaca. (2005) [Pubmed]
  8. The effect of moderate alcohol consumption on fat distribution and adipocytokines. Beulens, J.W., van Beers, R.M., Stolk, R.P., Schaafsma, G., Hendriks, H.F. Obesity (Silver Spring, Md.) (2006) [Pubmed]
  9. Insulin resistance and obesity: resistin, a hormone secreted by adipose tissue. Wolf, G. Nutr. Rev. (2004) [Pubmed]
  10. Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. Shuldiner, A.R., Yang, R., Gong, D.W. N. Engl. J. Med. (2001) [Pubmed]
  11. The hormone resistin links obesity to diabetes. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S., Lazar, M.A. Nature (2001) [Pubmed]
  12. Fat cells: afferent and efferent messages define new approaches to treat obesity. Lafontan, M. Annu. Rev. Pharmacol. Toxicol. (2005) [Pubmed]
  13. IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. Perrigoue, J.G., Li, J., Zaph, C., Goldschmidt, M., Scott, P., de Sauvage, F.J., Pearce, E.J., Ghilardi, N., Artis, D. J. Exp. Med. (2007) [Pubmed]
  14. Serum resistin and hepatic fat content in nondiabetic individuals. Perseghin, G., Lattuada, G., De Cobelli, F., Ntali, G., Esposito, A., Burska, A., Belloni, E., Canu, T., Ragogna, F., Scifo, P., Del Maschio, A., Luzi, L. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  15. Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance. Bahr, M.J., Ockenga, J., Böker, K.H., Manns, M.P., Tietge, U.J. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  16. Short-term dexamethasone administration does not alter serum adiponectin or resistin concentrations in overweight and obese subjects despite an increase in insulin resistance. Lewandowski, K.C., Szosland, K., Lewinski, A. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
  17. The effects of rosiglitazone and metformin on the plasma concentrations of resistin in patients with type 2 diabetes mellitus. Jung, H.S., Youn, B.S., Cho, Y.M., Yu, K.Y., Park, H.J., Shin, C.S., Kim, S.Y., Lee, H.K., Park, K.S. Metab. Clin. Exp. (2005) [Pubmed]
  18. Human Resistin Is a Systemic Immune-Derived Proinflammatory Cytokine Targeting both Leukocytes and Adipocytes. Nagaev, I., Bokarewa, M., Tarkowski, A., Smith, U. PLoS ONE (2006) [Pubmed]
  19. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Fontana, L., Eagon, J.C., Trujillo, M.E., Scherer, P.E., Klein, S. Diabetes (2007) [Pubmed]
  20. Resistin stimulation of 17alpha-hydroxylase activity in ovarian theca cells in vitro: relevance to polycystic ovary syndrome. Munir, I., Yen, H.W., Baruth, T., Tarkowski, R., Azziz, R., Magoffin, D.A., Jakimiuk, A.J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  21. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Mu, H., Ohashi, R., Yan, S., Chai, H., Yang, H., Lin, P., Yao, Q., Chen, C. Cardiovasc. Res. (2006) [Pubmed]
  22. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Verma, S., Li, S.H., Wang, C.H., Fedak, P.W., Li, R.K., Weisel, R.D., Mickle, D.A. Circulation (2003) [Pubmed]
  23. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Patel, L., Buckels, A.C., Kinghorn, I.J., Murdock, P.R., Holbrook, J.D., Plumpton, C., Macphee, C.H., Smith, S.A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  24. Resistin increases lipid accumulation and CD36 expression in human macrophages. Xu, W., Yu, L., Zhou, W., Luo, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  25. Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes. Di Simone, N., Di Nicuolo, F., Sanguinetti, M., Castellani, R., D'Asta, M., Caforio, L., Caruso, A. J. Endocrinol. (2006) [Pubmed]
  26. Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family. Chumakov, A.M., Kubota, T., Walter, S., Koeffler, H.P. Oncogene (2004) [Pubmed]
  27. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. Yannakoulia, M., Yiannakouris, N., Blüher, S., Matalas, A.L., Klimis-Zacas, D., Mantzoros, C.S. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  28. The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes. Kusminski, C.M., da Silva, N.F., Creely, S.J., Fisher, F.M., Harte, A.L., Baker, A.R., Kumar, S., McTernan, P.G. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  29. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. Haugen, F., Ranheim, T., Harsem, N.K., Lips, E., Staff, A.C., Drevon, C.A. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
WikiGenes - Universities