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Gene Review

nblA  -  phycobilisome degradation protein

Nostoc sp. PCC 7120

 
 
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Disease relevance of nblA

  • Expression and function of nblA in Anabaena sp. PCC 7120 was investigated [1].
  • The nblA family of genes encodes for small proteins necessary for the ordered degradation of phycobilisomes under certain stress conditions, a process known as chlorosis [2].
  • As is well documented for the unicellular, non-diazotrophic cyanobacteria Synechococcus elongatus PCC 7942 and Synechocystis sp. PCC 6803, a gene termed nblA plays a key role in PBS degradation [1].
 

High impact information on nblA

 

Analytical, diagnostic and therapeutic context of nblA

  • Northern blot analysis indicated that only the chromosomal nblA gene is up-regulated upon nitrogen starvation [1].

References

  1. NblA is essential for phycobilisome degradation in Anabaena sp. strain PCC 7120 but not for development of functional heterocysts. Baier, K., Lehmann, H., Stephan, D.P., Lockau, W. Microbiology (Reading, Engl.) (2004) [Pubmed]
  2. NblA from Anabaena sp. PCC 7120 is a mostly alpha-helical protein undergoing reversible trimerization in solution. Strauss, H., Misselwitz, R., Labudde, D., Nicklisch, S., Baier, K. Eur. J. Biochem. (2002) [Pubmed]
  3. Crystal structure of NblA from Anabaena sp. PCC 7120, a small protein playing a key role in phycobilisome degradation. Bienert, R., Baier, K., Volkmer, R., Lockau, W., Heinemann, U. J. Biol. Chem. (2006) [Pubmed]
 
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