The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HNRNPUL1  -  heterogeneous nuclear ribonucleoprotein U...

Homo sapiens

Synonyms: Adenovirus early region 1B-associated protein 5, E1B-55 kDa-associated protein 5, E1B-AP5, E1BAP5, FLJ12944, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HNRPUL1

  • Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction [1].
  • Immunoprecipitation experiments indicate that two distinct segments in the 55-kDa polypeptide which partly overlap regions responsible for p53 binding are required for complex formation with E1B-AP5 in Ad-infected cells and that this protein interaction is modulated by the adenovirus E4orf6 protein [2].

High impact information on HNRPUL1

  • The E1B-AP5 gene encodes a novel nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family that is highly related to hnRNP-U/SAF-A [2].
  • These data suggest that E1B-AP5 might play a role in RNA transport and that this function is modulated by E1B-55kDa in Ad-infected cells [2].
  • Disruption of the E1B-AP5-BRD7 complex increased E1B-AP5 repression activity for basic transcription and converted it from being an activator of the hormone-dependent promoter into being a strong repressor [3].
  • By in situ immunofluorescence we demonstrated that E1B-AP5 co-localizes with the nuclear fraction of HRMT1L1 [4].
  • The activity responsible for E1B-AP5 methylation forms a complex with E1B-AP5 in vivo [4].

Chemical compound and disease context of HNRPUL1

  • Arginine methylation of Ad (adenovirus) E1B 55-kDa-associated protein E1B-AP5 was recently described by us [Kzhyshkowska, Schutt, Liss, Kremmer, Stauber, Wolf and Dobner (2001) Biochem. J. 358, 305-314] [5].

Biological context of HNRPUL1

  • A novel mammalian hnRNP, E1B-AP5, recently identified by its interaction with adenovirus early protein E1B-55 kDa, has been proposed to have a regulatory role in adenoviral and host-cell mRNA processing/nuclear export [Gabler, Schutt, Groitl, Wolf, Shenk and Dobner (1998) J. Virol. 72, 7960-7971] [4].
  • The Src homology 3 (SH3) domain of HRMT1L1 was essential for its interaction with E1B-AP5 in vivo [4].
  • The binding site for E1B-AP5 has been mapped to the C-terminal region of p53 [6].
  • Transfection of E1B-AP5 into human tumour cells affected the cellular response to UV radiation, such that, although p53 expression was induced, little change in the level of p53-inducible genes could be observed [6].

Associations of HNRPUL1 with chemical compounds


Physical interactions of HNRPUL1

  • Using yeast two-hybrid screening we identified HRMT1L1 (PRMT2) as one of the proteins interacting with E1B-AP5 [4].

Regulatory relationships of HNRPUL1

  • In reporter assays, E1B-AP5 inhibited p53 transcriptional activity although not as efficiently as the Ad5E1B55K protein [6].

Other interactions of HNRPUL1


  1. Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. Shiffman, D., Rowland, C.M., Louie, J.Z., Luke, M.M., Bare, L.A., Bolonick, J.I., Young, B.A., Catanese, J.J., Stiggins, C.F., Pullinger, C.R., Topol, E.J., Malloy, M.J., Kane, J.P., Ellis, S.G., Devlin, J.J. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  2. E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. Gabler, S., Schütt, H., Groitl, P., Wolf, H., Shenk, T., Dobner, T. J. Virol. (1998) [Pubmed]
  3. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Kzhyshkowska, J., Rusch, A., Wolf, H., Dobner, T. Biochem. J. (2003) [Pubmed]
  4. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Kzhyshkowska, J., Schütt, H., Liss, M., Kremmer, E., Stauber, R., Wolf, H., Dobner, T. Biochem. J. (2001) [Pubmed]
  5. Protein arginine methylation during lytic adenovirus infection. Kzhyshkowska, J., Kremmer, E., Hofmann, M., Wolf, H., Dobner, T. Biochem. J. (2004) [Pubmed]
  6. The interaction of the hnRNP family member E1B-AP5 with p53. Barral, P.M., Rusch, A., Turnell, A.S., Gallimore, P.H., Byrd, P.J., Dobner, T., Grand, R.J. FEBS Lett. (2005) [Pubmed]
  7. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. Bachi, A., Braun, I.C., Rodrigues, J.P., Panté, N., Ribbeck, K., von Kobbe, C., Kutay, U., Wilm, M., Görlich, D., Carmo-Fonseca, M., Izaurralde, E. RNA (2000) [Pubmed]
WikiGenes - Universities