Gene Review:
TNPO1 - transportin 1
Homo sapiens
Synonyms:
IPO2, Importin beta-2, KPNB2, Karyopherin beta-2, M9 region interaction protein, ...
- The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. Izaurralde, E., Kutay, U., von Kobbe, C., Mattaj, I.W., Görlich, D. EMBO J. (1997)
- Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nicholas, J., Ruvolo, V.R., Burns, W.H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S.B., Guo, H.G., Hayward, G.S., Reitz, M.S. Nat. Med. (1997)
- Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities. Parlato, S., Santini, S.M., Lapenta, C., Di Pucchio, T., Logozzi, M., Spada, M., Giammarioli, A.M., Malorni, W., Fais, S., Belardelli, F. Blood (2001)
- A cell surface glycoprotein expressed by colorectal carcinomas including poorly differentiated, noncarcinoembryonic antigen-producing colorectal tumors. Salem, R.R., Wolf, B.C., Sears, H.F., Thomas, P., Bollinger, B., Zamcheck, N., Saravis, C.A., Chen, L.B., Steele, G. Cancer Res. (1988)
- Experimental Listeria meningoencephalitis. Macrophage inflammatory protein-1 alpha and -2 are produced intrathecally and mediate chemotactic activity in cerebrospinal fluid of infected mice. Seebach, J., Bartholdi, D., Frei, K., Spanaus, K.S., Ferrero, E., Widmer, U., Isenmann, S., Strieter, R.M., Schwab, M., Pfister, H., Fontana, A. J. Immunol. (1995)
- Validation of a technique to assess maximal inspiratory pressure in poorly cooperative patients. Truwit, J.D., Marini, J.J. Chest (1992)
- The mood-instability hypothesis in the origin of mood-congruent versus mood-incongruent psychotic distinction in mania: validation in a French National Study of 1090 patients. Azorin, J.M., Akiskal, H., Hantouche, E. Journal of affective disorders (2006)
- SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., Su, B. Cell (2006)
- A novel receptor-mediated nuclear protein import pathway. Pollard, V.W., Michael, W.M., Nakielny, S., Siomi, M.C., Wang, F., Dreyfuss, G. Cell (1996)
- Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Chook, Y.M., Blobel, G. Nature (1999)
- Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen. Davatelis, G., Wolpe, S.D., Sherry, B., Dayer, J.M., Chicheportiche, R., Cerami, A. Science (1989)
- Efficacy and toxicity of mitomycin, ifosfamide, and cisplatin (MIP) in patients with inoperable non-small cell lung cancer. Urban, T., Bedin, A., Baud, M., Chouaid, C., Febvre, M., Lebeau, B. Lung Cancer (1996)
- Ventilatory muscle strength and endurance in myasthenia gravis. Keenan, S.P., Alexander, D., Road, J.D., Ryan, C.F., Oger, J., Wilcox, P.G. Eur. Respir. J. (1995)
- Quality of life (QOL) assessment of MIP (mitomycin, ifosfamide and cisplatin) chemotherapy in advanced non-small cell lung cancers (NSCLC). Han, J.Y., Kim, H.K., Choi, B.G., Moon, H., Hong, Y.S., Lee, K.S. Jpn. J. Clin. Oncol. (1998)
- Efficiency of CT-angiography in the diagnosis of intracranial aneurysms. Sasiadek, M., Kowalewski, K., Turek, T., Hendrich, B., Podkowa, J., Maksymowicz, H. Med. Sci. Monit. (2002)
- Prognostic factors in multiple myeloma treated with prednisolone and sequential melphalan and ifosfamide: MIP combination chemotherapy. Adachi, T., Asano, K., Sezaki, T., Takahashi, I., Kimura, I. Acta Med. Okayama (1982)
- Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Bonifaci, N., Moroianu, J., Radu, A., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. Jäkel, S., Görlich, D. EMBO J. (1998)
- Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. Siomi, M.C., Eder, P.S., Kataoka, N., Wan, L., Liu, Q., Dreyfuss, G. J. Cell Biol. (1997)
- Definition of a consensus transportin-specific nucleocytoplasmic transport signal. Bogerd, H.P., Benson, R.E., Truant, R., Herold, A., Phingbodhipakkiya, M., Cullen, B.R. J. Biol. Chem. (1999)
- Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells. Broxmeyer, H.E., Sherry, B., Lu, L., Cooper, S., Carow, C., Wolpe, S.D., Cerami, A. J. Exp. Med. (1989)
- A novel class of RanGTP binding proteins. Görlich, D., Dabrowski, M., Bischoff, F.R., Kutay, U., Bork, P., Hartmann, E., Prehn, S., Izaurralde, E. J. Cell Biol. (1997)
- Transportin is a major nuclear import receptor for c-Fos: a novel mode of cargo interaction. Arnold, M., Nath, A., Wohlwend, D., Kehlenbach, R.H. J. Biol. Chem. (2006)
- Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Schmidtmayerova, H., Nottet, H.S., Nuovo, G., Raabe, T., Flanagan, C.R., Dubrovsky, L., Gendelman, H.E., Cerami, A., Bukrinsky, M., Sherry, B. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Broxmeyer, H.E., Sherry, B., Lu, L., Cooper, S., Oh, K.O., Tekamp-Olson, P., Kwon, B.S., Cerami, A. Blood (1990)
- Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis. Lyall, R.A., Donaldson, N., Polkey, M.I., Leigh, P.N., Moxham, J. Brain (2001)
- In vitro generation of a highly immunogenic subline of L1210 leukemia following exposure to 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide. Contessa, A.R., Bonmassar, A., Giampietri, A., Circolo, A., Goldin, A., Fioretti, M.C. Cancer Res. (1981)
- Water-compatible molecularly imprinted polymers obtained via high-throughput synthesis and experimental design. Dirion, B., Cobb, Z., Schillinger, E., Andersson, L.I., Sellergren, B. J. Am. Chem. Soc. (2003)
- Valproate decreases inositol biosynthesis. Shaltiel, G., Shamir, A., Shapiro, J., Ding, D., Dalton, E., Bialer, M., Harwood, A.J., Belmaker, R.H., Greenberg, M.L., Agam, G. Biol. Psychiatry (2004)
- The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import. Fontoura, B.M., Blobel, G., Yaseen, N.R. J. Biol. Chem. (2000)
- Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. Dean, K.A., von Ahsen, O., Görlich, D., Fried, H.M. J. Cell. Sci. (2001)
- Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. Rebane, A., Aab, A., Steitz, J.A. RNA (2004)
- Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. Fridell, R.A., Truant, R., Thorne, L., Benson, R.E., Cullen, B.R. J. Cell. Sci. (1997)
- Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis. Koch, A.E., Kunkel, S.L., Harlow, L.A., Mazarakis, D.D., Haines, G.K., Burdick, M.D., Pope, R.M., Strieter, R.M. J. Clin. Invest. (1994)
- Human T-cell heterogeneity as delineated with a specific human thymus lymphocyte antiserum. In vitro effects on mitogen response mixed leukocyte culture, cell-mediated lymphocytotoxicity, and lymphokine production. Woody, J.N., Ahmed, A., Knudsen, R.C., Strong, D.M., Sell, K.W. J. Clin. Invest. (1975)
- Visualization of chemokine binding sites on human brain microvessels. Andjelkovic, A.V., Spencer, D.D., Pachter, J.S. J. Cell Biol. (1999)
- Is the tolerance to MIP chemotherapy different between English and other European populations? Berghmans, T., Sculier, J.P. J. Clin. Oncol. (2005)