Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Tlsm1 - thymic lymphoma susceptible 1

Mus musculus

Yamada, Y. et al., Kamisaku, H. et al., Hiai, H., Lu, L.M. et al., Hiai, H. et al.

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Disease relevance of Tlsm1

Close scrutiny of this region of AKXD recombinant inbred strains for spontaneous T lymphomas revealed the presence of Tlsm-1-like gene most likely between D7MIT71 (map position 62) and D7MIT13 (map position 70) [1].

High impact information on Tlsm1

Linkage analysis with microsatellite markers assigned Tlsm-1 to the map position 61 cM from centromere of the chromosome 7 [1].
To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models [2].
Limiting dilution analysis of T-cell progenitors in the bone marrow of thymic lymphoma-susceptible B10 and -resistant C3H mice after fractionated whole-body X-irradiation [3].
The role of the thymus in the development of T-lymphomas in the mouse, and the possible relevance of Tlsm-1 in this step, is discussed [4].

Analytical, diagnostic and therapeutic context of Tlsm1

As an approach to the role of Tlsm1, we studied the effect of thymectomy at 1 week of age in (SL/KhxAKR/Ms)F1 hybrids [5].

References

T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models. Yamada, Y., Shisa, H., Matsushiro, H., Kamoto, T., Kobayashi, Y., Kawarai, A., Hiai, H. J. Exp. Med. (1994) [Pubmed]
To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models. Hiai, H., Yamada, Y., Shisa, H., Kamoto, T., Abujiang, P., Lu, L.M. Leukemia (1997) [Pubmed]
Limiting dilution analysis of T-cell progenitors in the bone marrow of thymic lymphoma-susceptible B10 and -resistant C3H mice after fractionated whole-body X-irradiation. Kamisaku, H., Aizawa, S., Kitagawa, M., Ikarashi, Y., Sado, T. Int. J. Radiat. Biol. (1997) [Pubmed]
Genetic predisposition to lymphomas in mice. Hiai, H. Pathol. Int. (1996) [Pubmed]
Mixed phenotype lymphomas in thymectomized (SL/KhxAKR/Ms)F1 mice. Lu, L.M., Hiai, H. Jpn. J. Cancer Res. (1999) [Pubmed]

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