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Gene Review

Egln1  -  egl-9 family hypoxia-inducible factor 1

Mus musculus

Synonyms: AI503754, C1orf12, Egl nine homolog 1, HIF-PH2, HIF-prolyl hydroxylase 2, ...
 
 
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Disease relevance of Egln1

  • This protein was 57% homologous to the putative protein encoded by the ORF13 gene of herpesvirus Saimiri, a T lymphotropic virus [1].
  • The Brucella abortus virB operon, consisting of 11 genes, virB1 to virB11, and two putative genes, orf12 (virB12) and orf13, encodes a type IV secretion system (T4SS) that is required for intracellular replication and persistent infection in the mouse model [2].
 

High impact information on Egln1

References

  1. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. Rouvier, E., Luciani, M.F., Mattéi, M.G., Denizot, F., Golstein, P. J. Immunol. (1993) [Pubmed]
  2. Brucella abortus virB12 is expressed during infection but is not an essential component of the type IV secretion system. Sun, Y.H., Rolán, H.G., den Hartigh, A.B., Sondervan, D., Tsolis, R.M. Infect. Immun. (2005) [Pubmed]
  3. Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2. Dupuy, D., Aubert, I., Dupérat, V.G., Petit, J., Taine, L., Stef, M., Bloch, B., Arveiler, B. Genomics (2000) [Pubmed]
  4. A candidate mouse model for Hartnup disorder deficient in neutral amino acid transport. Symula, D.J., Shedlovsky, A., Guillery, E.N., Dove, W.F. Mamm. Genome (1997) [Pubmed]
  5. Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. Kennedy, J., Rossi, D.L., Zurawski, S.M., Vega, F., Kastelein, R.A., Wagner, J.L., Hannum, C.H., Zlotnik, A. J. Interferon Cytokine Res. (1996) [Pubmed]
 
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