The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Egln1  -  egl-9 family hypoxia-inducible factor 1

Mus musculus

Synonyms: AI503754, C1orf12, Egl nine homolog 1, HIF-PH2, HIF-prolyl hydroxylase 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Egln1

  • This protein was 57% homologous to the putative protein encoded by the ORF13 gene of herpesvirus Saimiri, a T lymphotropic virus [1].
  • The Brucella abortus virB operon, consisting of 11 genes, virB1 to virB11, and two putative genes, orf12 (virB12) and orf13, encodes a type IV secretion system (T4SS) that is required for intracellular replication and persistent infection in the mouse model [2].

High impact information on Egln1


  1. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. Rouvier, E., Luciani, M.F., Mattéi, M.G., Denizot, F., Golstein, P. J. Immunol. (1993) [Pubmed]
  2. Brucella abortus virB12 is expressed during infection but is not an essential component of the type IV secretion system. Sun, Y.H., Rolán, H.G., den Hartigh, A.B., Sondervan, D., Tsolis, R.M. Infect. Immun. (2005) [Pubmed]
  3. Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2. Dupuy, D., Aubert, I., Dupérat, V.G., Petit, J., Taine, L., Stef, M., Bloch, B., Arveiler, B. Genomics (2000) [Pubmed]
  4. A candidate mouse model for Hartnup disorder deficient in neutral amino acid transport. Symula, D.J., Shedlovsky, A., Guillery, E.N., Dove, W.F. Mamm. Genome (1997) [Pubmed]
  5. Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. Kennedy, J., Rossi, D.L., Zurawski, S.M., Vega, F., Kastelein, R.A., Wagner, J.L., Hannum, C.H., Zlotnik, A. J. Interferon Cytokine Res. (1996) [Pubmed]
WikiGenes - Universities