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Gene Review

cdh1  -  cadherin 1, type 1, E-cadherin (epithelial)

Danio rerio

Synonyms: SO:0000704
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High impact information on cdh1

  • Our experiments illustrate the importance of cdh1 in regulating morphogenetic cell movements and tissue formation in the early embryo [1].
  • In early cdh1 MO-injected embryos, the cleavage plane orientation between blastomeres was irregular and adhesion defects prevented normal compaction [1].
  • We investigated spatial and temporal expression of cdh1 during early embryogenesis [2].
  • Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned [2].

Analytical, diagnostic and therapeutic context of cdh1

  • Immunohistochemistry with an anti-beta-catenin antibody and electron microscopy revealed that adhesion between the DCs and the EVL was mostly disrupted but the adhesion between DCs was relatively unaffected in the MZcdh1(rk3) mutant and cdh1 morphant embryos [3].


  1. E-cadherin regulates cell movements and tissue formation in early zebrafish embryos. Babb, S.G., Marrs, J.A. Dev. Dyn. (2004) [Pubmed]
  2. Zebrafish E-cadherin: expression during early embryogenesis and regulation during brain development. Babb, S.G., Barnett, J., Doedens, A.L., Cobb, N., Liu, Q., Sorkin, B.C., Yelick, P.C., Raymond, P.A., Marrs, J.A. Dev. Dyn. (2001) [Pubmed]
  3. E-cadherin is required for gastrulation cell movements in zebrafish. Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., Hibi, M. Mech. Dev. (2005) [Pubmed]
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