Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

RHPN1 - rhophilin, Rho GTPase binding protein 1

Homo sapiens

Synonyms: GTP-Rho-binding protein 1, KIAA1929, ODF5, RHOPHILIN, RHPN, ...

Fujita, A. et al., Peck, J.W. et al.

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High impact information on RHPN1

Glutathione S-transferase-capture experiments revealed that Rhophilin-1 and Rhophilin-2 interacted with both GDP- and GTP-bound RhoA in vitro [1].
Although Rhophilin-2-expressing HeLa cells showed a loss of actin stress fibers, Rhophilin-1 expression had no noticeable effect on the actin cytoskeleton [1].
These results suggest that rhophilin and ropporin may form a complex in sperm flagella [2].
To test this hypothesis, we employed a yeast two hybrid system using the rhophilin PDZ domain as a bait, and screened a mouse testis cDNA library [2].

Biological context of RHPN1

Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella [2].

References

The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. Peck, J.W., Oberst, M., Bouker, K.B., Bowden, E., Burbelo, P.D. J. Biol. Chem. (2002) [Pubmed]
Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. Fujita, A., Nakamura, K., Kato, T., Watanabe, N., Ishizaki, T., Kimura, K., Mizoguchi, A., Narumiya, S. J. Cell. Sci. (2000) [Pubmed]

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