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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FCRL1  -  Fc receptor-like 1

Homo sapiens

Synonyms: CD307a, FCRH1, Fc receptor homolog 1, Fc receptor-like protein 1, FcR-like protein 1, ...
 
 
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High impact information on FCRL1

  • The observation that FCRL representatives are members of an ancient multigene family that share a common ancestor with the classical FCR is underscored by their linked genomic locations, gene structure, shared extracellular domain composition, and utilization of common cytoplasmic tyrosine-based signaling elements [1].
  • Spontaneous release of Fc receptor-like material from human lymphoblastoid cell lines [2].
  • FcRH1/IRTA5 was expressed throughout the B-cell lineage starting at the pro-B-cell stage but was down-regulated in plasma cells [3].
  • A group of genes encoding proteins structurally related to the leukocyte Fc receptors (FcRs) and termed the IFGP family was identified in human and mouse [4].
  • The organization of the human genes shows that the IFGP family evolved through differential gain and loss of exons due to recombination and/or mutation accumulation in the duplicated copies [4].
 

Biological context of FCRL1

  • While the human IFGP members appear to be B-cell antigens, the mouse genes have a broader tissue distribution with predominant expression in brain [4].
 

Anatomical context of FCRL1

  • OBJECTIVE: To identify an Fc receptor-like molecule in human cervical mucus [5].
  • Isolation and purification of an early pregnancy factor-like molecule from culture supernatants obtained from lymphocytes of pregnant women: II. Identification of the molecule as a Fc-receptor-like molecule: a preliminary report [6].

References

  1. Fc receptor-like molecules. Davis, R.S. Annu. Rev. Immunol. (2007) [Pubmed]
  2. Spontaneous release of Fc receptor-like material from human lymphoblastoid cell lines. Molenaar, J.L., van Galen, M., Hannema, A.J., Zeijlemaker, W., Pondman, K.W. Eur. J. Immunol. (1977) [Pubmed]
  3. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Polson, A.G., Zheng, B., Elkins, K., Chang, W., Du, C., Dowd, P., Yen, L., Tan, C., Hongo, J.A., Koeppen, H., Ebens, A. Int. Immunol. (2006) [Pubmed]
  4. A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. Guselnikov, S.V., Ershova, S.A., Mechetina, L.V., Najakshin, A.M., Volkova, O.Y., Alabyev, B.Y., Taranin, A.V. Immunogenetics (2002) [Pubmed]
  5. Binding of human secretory leukocyte protease inhibitor in uterine cervical mucus to immunoglobulins: pathophysiology in immunologic infertility and local immune defense. Hirano, M., Kamada, M., Maegawa, M., Gima, H., Aono, T. Fertil. Steril. (1999) [Pubmed]
  6. Isolation and purification of an early pregnancy factor-like molecule from culture supernatants obtained from lymphocytes of pregnant women: II. Identification of the molecule as a Fc-receptor-like molecule: a preliminary report. Aranha, C., Bordekar, A., Shahani, S. J. Assist. Reprod. Genet. (1998) [Pubmed]
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