Disease relevance of Cervix Mucus

• Overall, these results suggest that a direct inhibitory effect of nicotine on sperm penetrability through cervical mucus is not responsible for the apparent increase in cervical factor infertility present in smoking women [1].
• Smoking and cervical intraepithelial neoplasia: nicotine and cotinine in serum and cervical mucus in smokers and nonsmokers [2].
• RESULTS: Chondroitin sulfate concentrations in cervical mucus were increased significantly (P <. 05) in the threatened premature labor group compared with the preterm and term groups [3].
• SLPI is a protein found in various human fluids, including parotid secretions, cervical mucus, seminal plasma and ascites [4].
• The inhibition of sperm functions was evaluated by computer-assisted semen analysis (CASA) for sperm motility, in cervical mucus penetration assay, and by colorimetric tetrazolium salt and lactate dehydrogenase release assays routinely employed for testing the toxicity of drugs [5].

Psychiatry related information on Cervix Mucus

• OBJECTIVE: Interleukin-1 alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in specimens of cervical mucus were assayed to assess defense mechanisms against infection in the cervical canal during pregnancy [6].

High impact information on Cervix Mucus

• Malonaldehyde in cervical mucus [7].
• Human cervical mucin was solubilized from the gel phase of pooled midcycle cervical mucus using 6 M guanidine hydrochloride and 10 mM dithiothreitol and was then alkylated with iodoacetamide [8].
• The Amount of MUC5B mucin in cervical mucus peaks at midcycle [9].
• To measure MUC5B protein within the cervical mucus through the hormone cycle, we developed a polyclonal antibody specific to the mucin [9].
• These increased preovulatory serum progesterone levels could contribute to the lower cervical mucus score in the induced compared with spontaneous cycle, whereas their effect on the endometrium is still unclear [10].

Biological context of Cervix Mucus

• We measured basal body temperature, cervical mucus, follicular diameter, and serum LH, FSH, 17 beta-estradiol, and progesterone daily in 40 spontaneous ovulatory cycles in 27 infertile women and in 40 clomiphene citrate-induced ovulatory cycles in 31 women [10].
• Antibody responses to infected subjects' homologous isolates were observed in cervical mucus; IgA1 levels increased while IgG levels decreased [11].
• Endocervical expression of Fut2 in estrus and pregnancy may modify cervical mucus barrier properties from microbial infection analogous to the potential role of mucosal glycans in humans [12].
• Seasonal variation in the nature of cervical mucus response to estradiol benzoate in normal and clover-affected ovariectomized ewes [13].
• OBJECTIVE: To analyze the effects of clomiphene citrate (CC) on cervical mucus (CM) and endometrial morphology independently of hormonal changes encountered when CC is administered for ovulation induction [14].

Anatomical context of Cervix Mucus

• Estrogen increases secretion of cervical mucus in women, and the effect depends on fragmentation of the cytoskeleton [15].
• These findings supported the contention that citrate is the major regulator of the levels of ionized calcium in seminal plasma and primarily responsible for maintaining the calcium gradient between the seminal plasma and cervical mucus [16].
• Influence of caffeine on movement characteristics, fertilizing capacity and ability to penetrate cervical mucus of human spermatozoa [17].
• We examined nitroblue tetrazolium reduction activity in leukocytes from cervical mucus as well as peripheral blood from pregnant and nonpregnant women by histochemical methods [18].
• OBJECTIVE: Lactoferrin, an iron-binding glycoprotein found in cervical mucus and amniotic fluid, plays a defensive role against mucosal infections [19].

Associations of Cervix Mucus with chemical compounds

• Lectin blot assay of immunoprecipitated MUC5B demonstrated that the mucin is a carrier of the T antigen and N-acetyllactosamine oligosaccharides in cervical mucus secretions [20].
• Polymeric structure of a high-molecular-weight glycoprotein from bovine cervical mucus [21].
• Hydrodynamic properties of human cervical-mucus glycoproteins in 6M-guanidinium chloride [22].
• Sperm-cervical mucus and sperm-hyaluronic acid interactions were assessed by using appropriate microchannel-chamber structures filled with either cervical mucus or hyaluronic acid [23].
• The macromolecular properties of cervical-mucus glycoproteins (mucins) were studied as a function of the concentration of guanidinium chloride with conventional light-scattering, photon-correlation spectroscopy and sedimentation-velocity centrifugation [24].

Gene context of Cervix Mucus

• Reverse zymography showed that tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and TIMP-2 are detectable in the cervical mucus plug [25].
• Although cervical mucus becomes thick and scant during the luteal phase, CFTR gene expression is present in these secretions [26].
• Western blot analysis detected only TFF3 in tissue extracts of the endocervix and as a constituent of human cervical mucus [27].
• Soluble forms of DAF and CD59 were found to be present in cervical mucus [28].
• Message levels for MUC4, a major membrane-spanning mucin of the endocervix, peak at midcycle, but protein levels of MUC4 in human cervical mucus have not been measured [29].

Analytical, diagnostic and therapeutic context of Cervix Mucus

• Malonaldehyde in cervical mucus associated with copper IUD [30].
• When IgA1 in cervical mucus was examined by Western blotting, no evidence of cleavage fragments characteristic of IgA1 protease activity was seen in gonococcus-infected or control patients [31].
• Subunits of human cervical-mucus glycoproteins obtained by reductive cleavage of whole mucins and high-Mr glycopeptides (T-domains) obtained after their trypsin digestion were studied with electron microscopy after spreading the macromolecules in a monolayer of benzyldimethylalkylammonium chloride [32].
• The results of a cervical mucus scoring system and of basal body temperature (BBT) chart interpretation were compared with those of a short-incubation radioimmunoassay for luteinizing hormone (LH) in 198 ovulatory menstrual cycles [33].
• Chondroitin sulfate isomer (chondroitin 0-sulfate, 4-sulfate, and 6-sulfate) concentrations in cervical mucus were measured by high-performance liquid chromatography [3].

References