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Gene Review

OSR2  -  odd-skipped related transciption factor 2

Homo sapiens

Synonyms: FLJ90037, Protein odd-skipped-related 2
 
 
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Disease relevance of OSR2

  • We report that a targeted null mutation in Osr2 impairs palatal shelf growth and causes delay in palatal shelf elevation, resulting in cleft palate [1].
 

High impact information on OSR2

  • Whereas palatal outgrowth initiates normally in the Osr2 mutant embryos, a significant reduction in palatal mesenchyme proliferation occurs specifically in the medial halves of the downward growing palatal shelves at E13.5, which results in retarded, mediolaterally symmetric palatal shelves before palatal shelf elevation [1].
  • Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis [1].
  • Two Osr genes are present in mammalian genomes, and it was recently reported that Osr1, but not Osr2, is required for murine kidney development [2].
  • The putative OSR2 protein shares 65% amino acid sequence identity overall and 98% sequence identity in the zinc finger region, respectively, with the previously reported Osr1 gene product [3].
 

Biological context of OSR2

 

Other interactions of OSR2

  • OSR1 showed 63.6% total amino-acid identity with OSR2 [4].

References

  1. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Lan, Y., Ovitt, C.E., Cho, E.S., Maltby, K.M., Wang, Q., Jiang, R. Development (2004) [Pubmed]
  2. Odd-skipped genes encode repressors that control kidney development. Tena, J.J., Neto, A., de la Calle-Mustienes, E., Bras-Pereira, C., Casares, F., Gómez-Skarmeta, J.L. Dev. Biol. (2007) [Pubmed]
  3. Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development. Lan, Y., Kingsley, P.D., Cho, E.S., Jiang, R. Mech. Dev. (2001) [Pubmed]
  4. Molecular cloning and characterization of OSR1 on human chromosome 2p24. Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
 
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