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Gene Review:

OSR1 - odd-skipped related transciption factor 1

Homo sapiens

Synonyms: ODD, Protein odd-skipped-related 1

Katoh, M., Lan, Y. et al., Tena, J.J. et al., Hu, W. et al.

Katoh,

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Disease relevance of OSR1

Among 10 cases of primary gastric cancer, OSR1 mRNA was up-regulated in 5 cases, and was down-regulated in 2 cases [1].

High impact information on OSR1

The developmental timing of palatal growth retardation correlates exactly with the spatiotemporal pattern of Osr1 gene expression during palate development [2].
Two Osr genes are present in mammalian genomes, and it was recently reported that Osr1, but not Osr2, is required for murine kidney development [3].
Molecular cloning and characterization of OSR1 on human chromosome 2p24 [1].
OSR1 was found to encode 266 amino-acid protein with three C2H2-type zinc fingers, a tyrosine phosphorylation site (Tyr 203), and several putative PXXP SH3 binding motifs [1].
OSR1 gene consisting of three exons was located on human chromosome 2p24 [1].

Biological context of OSR1

Here, human OSR1, related to Drosophila odd, was isolated using bioinformatics and cDNA-PCR [1].

Anatomical context of OSR1

OSR1 mRNA of 2.3-kb in size was detected in adult colon, small intestine, prostate, testis, and fetal lung [1].
The novel molecule porcine OSR1 up-regulated expression on porcine endothelial cell by human peripheral blood mononuclear cell activation [4].

Analytical, diagnostic and therapeutic context of OSR1

This is the first report on molecular cloning and characterization of human OSR1 [1].

References

Molecular cloning and characterization of OSR1 on human chromosome 2p24. Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Lan, Y., Ovitt, C.E., Cho, E.S., Maltby, K.M., Wang, Q., Jiang, R. Development (2004) [Pubmed]
Odd-skipped genes encode repressors that control kidney development. Tena, J.J., Neto, A., de la Calle-Mustienes, E., Bras-Pereira, C., Casares, F., Gómez-Skarmeta, J.L. Dev. Biol. (2007) [Pubmed]
The novel molecule porcine OSR1 up-regulated expression on porcine endothelial cell by human peripheral blood mononuclear cell activation. Hu, W., Cheng, J., Lu, X., Li, S., Zeng, L., Li, Y. Transplant. Proc. (2004) [Pubmed]

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OSR1	Bos taurus
OSR1	Canis lupus familiaris
osr1	Danio rerio
OSR1	Gallus gallus
Osr1	Mus musculus
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osr1	Xenopus (Silurana) tropicalis

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