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Gene Review

Slc9a3r2  -  solute carrier family 9, subfamily A (NHE3...

Rattus norvegicus

Synonyms: NHE3 kinase A regulatory protein E3KARP, NHERF-2, Na(+)/H(+) exchange regulatory cofactor NHE-RF2, Nherf2, SIP-1, ...
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High impact information on Slc9a3r2

  • We conclude that DVR pericytes and endothelia coexpress TRPC4 and NHERF-2 mRNA and protein and that these proteins colocalize and coimmunoprecipitate, indicating a possible physical association [1].
  • Immunohistochemical studies demonstrated expression of TRPC4 and NHERF-2 proteins in both the endothelial cells and pericytes [1].
  • RT-PCR revealed mRNA for TRPC4 and NHERF-2, but not for TRPC5 or NHERF-1, in microdissected DVR [1].
  • Recent work indicates the involvement of the SMN protein and its associated protein SIP1 in spliceosomal snRNP biogenesis [2].
  • In these nuclear dots, SMN colocalized with SIP1 and with fibrillarin, a marker of coiled bodies [2].

Associations of Slc9a3r2 with chemical compounds

  • RESULTS: STC as well as PMA (protein kinase C activator) and anisomycin (tyrosine kinase activator) significantly reduced infarct size (6.9 +/- 2.9%, 9.6 +/- 2.1%, 14.0 +/- 4.4%) compared with controls (42.4 +/- 2.9%, P < 0.05) [3].

Analytical, diagnostic and therapeutic context of Slc9a3r2


  1. Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta. Lee-Kwon, W., Wade, J.B., Zhang, Z., Pallone, T.L., Weinman, E.J. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Subcellular distribution of survival motor neuron (SMN) protein: possible involvement in nucleocytoplasmic and dendritic transport. Béchade, C., Rostaing, P., Cisterni, C., Kalisch, R., La Bella, V., Pettmann, B., Triller, A. Eur. J. Neurosci. (1999) [Pubmed]
  3. Cardioprotection by St Thomas' solution is mediated by protein kinase C and tyrosine kinase. Hedayati, N., Schomisch, S.J., Carino, J.L., Timothy Sherwood, J., Lesnefsky, E.J., Cmolik, B.L. J. Surg. Res. (2003) [Pubmed]
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