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Gene Review

Alas1  -  aminolevulinic acid synthase 1

Mus musculus

Synonyms: 5-aminolevulinate synthase, 5-aminolevulinate synthase, nonspecific, mitochondrial, 5-aminolevulinic acid synthase 1, ALAS, ALAS-H, ...
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High impact information on Alas1


Associations of Alas1 with chemical compounds


Analytical, diagnostic and therapeutic context of Alas1

  • The amount of CYP1A1 and CYP1A2 mRNA, as determined by real-time PCR, was not significantly changed; mRNA encoding the housekeeping 5-aminolevulinic acid synthase was elevated 10-fold [6].


  1. Aspartate-279 in aminolevulinate synthase affects enzyme catalysis through enhancing the function of the pyridoxal 5'-phosphate cofactor. Gong, J., Hunter, G.A., Ferreira, G.C. Biochemistry (1998) [Pubmed]
  2. Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation. Stuckey, R., Aldridge, T., Lim, F.L., Moore, D.J., Tinwell, H., Doherty, N., Davies, R., Smith, A.G., Kimber, I., Ashby, J., Orphanides, G., Moggs, J.G. Mol. Cell. Endocrinol. (2006) [Pubmed]
  3. Fluorimetric determination of hepatic delta-aminolevulinic acid synthase activity by high-performance liquid chromatography. Tomokuni, K., Hirai, Y., Ichiba, M. J. Chromatogr. (1991) [Pubmed]
  4. Differential induction responses of delta-aminolevulinate synthase mRNAs during erythroid differentiation: use of nonradioactive in situ hybridization. Mitani, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S. Am. J. Hematol. (1992) [Pubmed]
  5. Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis. Vazquez, E., Gerez, E., Caballero, F., Polo, C., Batlle, A. Cancer Biochem. Biophys. (1999) [Pubmed]
  6. Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice. Krijt, J., Psenák, O., Vokurka, M., Chlumská, A., Fakan, F. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
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