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Gene Review

ALAS1  -  aminolevulinate, delta-, synthase 1

Gallus gallus

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Disease relevance of ALAS1

  • ALAS1 drug-responsive enhancer sequences were identified by transient transfection of reporter gene constructs in the drug-responsive leghorn male hepatoma cell line [1].
  • Parameters used to assess toxicity were: (1) release of lactate dehydrogenase (LDH); (2) decreased induction of 5-aminolevulinic acid synthase (ALAS), measured as porphyrin accumulation; and (3) decreased protein synthesis [2].

High impact information on ALAS1


Chemical compound and disease context of ALAS1


Biological context of ALAS1


Anatomical context of ALAS1


Associations of ALAS1 with chemical compounds


Other interactions of ALAS1

  • In the present study, we report that the protein kinase inhibitor 2-aminopurine markedly inhibits the phenobarbital-induced activation of CYP2H1 and ALAS-1 genes as measured by Northern blot analysis, but does not alter the basal expression of these genes in the absence of drug [20].

Analytical, diagnostic and therapeutic context of ALAS1


  1. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. Fraser, D.J., Zumsteg, A., Meyer, U.A. J. Biol. Chem. (2003) [Pubmed]
  2. Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450. LeDuc, B.W., Sinclair, P.R., Walton, H.S., Sinclair, J.F., Greenblatt, D.J., Shuster, L. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  3. Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. Cable, E.E., Pepe, J.A., Karamitsios, N.C., Lambrecht, R.W., Bonkovsky, H.L. J. Clin. Invest. (1994) [Pubmed]
  4. Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes. Riddle, R.D., Yamamoto, M., Engel, J.D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Repression of hepatic delta-aminolevulinate synthase by heme and metalloporphyrins: relationship to inhibition of heme oxygenase. Cable, E.E., Cable, J.W., Bonkovsky, H.L. Hepatology (1993) [Pubmed]
  6. Mechanism of iron potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells. Bonkovsky, H.L. Hepatology (1989) [Pubmed]
  7. Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. Kolluri, S., Sadlon, T.J., May, B.K., Bonkovsky, H.L. Biochem. J. (2005) [Pubmed]
  8. Nucleotide sequence of the chicken 5-aminolevulinate synthase gene. Maguire, D.J., Day, A.R., Borthwick, I.A., Srivastava, G., Wigley, P.L., May, B.K., Elliott, W.H. Nucleic Acids Res. (1986) [Pubmed]
  9. Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). Fraser, D.J., Podvinec, M., Kaufmann, M.R., Meyer, U.A. J. Biol. Chem. (2002) [Pubmed]
  10. Biogenesis of mitochondrial proteins. Identification of the mature and precursor forms of the subunit of delta-aminolevulinate synthase from embryonic chick liver. Ades, I.Z., Harpe, K.G. J. Biol. Chem. (1981) [Pubmed]
  11. A unique gene for 5-aminolevulinate synthase in chickens. Evidence for expression of an identical messenger RNA in hepatic and erythroid tissues. Elferink, C.J., Srivastava, G., Maguire, D.J., Borthwick, I.A., May, B.K., Elliott, W.H. J. Biol. Chem. (1987) [Pubmed]
  12. The effect of N-methylprotoporphyrin and succinyl-acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture. De Matteis, F., Marks, G.S. FEBS Lett. (1983) [Pubmed]
  13. Effect of heme on the activity of chick embryo liver mitochondrial delta-aminolevulinate synthase. Pirola, B.A., Srivastava, G., Borthwick, I.A., Brooker, J.D., May, B.K., Elliott, W.H. FEBS Lett. (1984) [Pubmed]
  14. delta-Aminolevulinate synthase isozymes in the liver and erythroid cells of chicken. Watanabe, N., Hayashi, N., Kikuchi, G. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  15. Differential effects of chromium(VI) on constitutive and inducible gene expression in chick embryo liver in vivo and correlation with chromium(VI)-induced DNA damage. Hamilton, J.W., Wetterhahn, K.E. Mol. Carcinog. (1989) [Pubmed]
  16. The influence of propranolol on the concentration of heme and on the activity of delta aminolevulinate synthase in monolayers of chick embryo liver cells. Epstein, O., Schoenfeld, N., Greenblat, Y., Lahav, M., Atsmon, A. Biochem. Pharmacol. (1982) [Pubmed]
  17. The substituted pyridines metyrapone and nicotinamide are inducers of 5-aminolevulinate synthase and cytochrome P-450 in hepatocyte culture. Giger, U., Meyer, U.A. Biochem. Pharmacol. (1982) [Pubmed]
  18. Superinduction by cycloheximide of cytochrome P4502H1 and 5-aminolevulinate synthase gene transcription in chick embryo liver. Dogra, S.C., Hahn, C.N., May, B.K. Arch. Biochem. Biophys. (1993) [Pubmed]
  19. Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes. Jacobs, J.M., Marek, D., Walton, H.S., Sinclair, P.R., Sinclair, J.F. Arch. Biochem. Biophys. (1999) [Pubmed]
  20. Phenobarbital-induced activation of CYP2H1 and 5-aminolevulinate synthase genes in chick embryo hepatocytes is blocked by an inhibitor of protein phosphorylation. Dogra, S.C., May, B.K. Arch. Biochem. Biophys. (1996) [Pubmed]
  21. Molecular cloning of hepatic 5-aminolevulinate synthase. Borthwick, I.A., Srivastava, G., Hobbs, A.A., Pirola, B.A., Brooker, J.D., May, B.K., Elliott, W.H. Eur. J. Biochem. (1984) [Pubmed]
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