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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Kcnj9  -  potassium channel, inwardly rectifying...

Rattus norvegicus

Synonyms: G protein-activated inward rectifier potassium channel 3, GIRK-3, Girk3, Inward rectifier K(+) channel Kir3.3, Kir3.3, ...
 
 
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High impact information on Kcnj9

  • In contrast, the Kir3.3 subunit potently inhibits plasma membrane expression by diverting the heterotetrameric channels to lysosomes [1].
  • Analysis of macroscopic current amplitudes and channel gating kinetics indicated that individual subunits or combinations of Kir3.2, Kir3.3, and Kir3.4 formed functional channels ineffectively [2].
  • Whereas staining for Kir3.1 was profoundly present in an endoplasmic reticulum-like structure and Kir3.2 was strongly expressed in the cytoplasm and the cytomembrane of somata, dendrites and axons of RGCs, faint, sparse labelling for Kir3.3 was seen in the cytomembrane [3].
  • We have cloned by homology screening from a rat brain cDNA library a GIRK3-type (Kir 3.3) inwardly rectifying K+ channel subunit with high structural similarity to other subfamily members whose activity is thought to be controlled by receptor-stimulated G proteins [4].

References

  1. Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Ma, D., Zerangue, N., Raab-Graham, K., Fried, S.R., Jan, Y.N., Jan, L.Y. Neuron (2002) [Pubmed]
  2. Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels. Wischmeyer, E., Döring, F., Wischmeyer, E., Spauschus, A., Thomzig, A., Veh, R., Karschin, A. Mol. Cell. Neurosci. (1997) [Pubmed]
  3. Inwardly rectifying potassium channels in rat retinal ganglion cells. Chen, L., Yu, Y.C., Zhao, J.W., Yang, X.L. Eur. J. Neurosci. (2004) [Pubmed]
  4. Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain. Dissmann, E., Wischmeyer, E., Spauschus, A., Pfeil, D.V., Karschin, C., Karschin, A. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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