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Gene Review

Kcnj9  -  potassium inwardly-rectifying channel,...

Mus musculus

Synonyms: 1700085N21Rik, G protein-activated inward rectifier potassium channel 3, GIRK-3, Girk3, Inward rectifier K(+) channel Kir3.3, ...
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Psychiatry related information on Kcnj9


High impact information on Kcnj9


Biological context of Kcnj9


Anatomical context of Kcnj9

  • G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons [5].
  • Coexpression of GIRK2wv with GIRK1, GIRK2, or GIRK3 in Xenopus oocytes along with expression of subunit combinations linked as dimers and tetramers was used to investigate the effects of the pore mutation on channel selectivity and gating as a function of relative subunit position and number within a heterotetrameric complex [6].

Associations of Kcnj9 with chemical compounds


Other interactions of Kcnj9

  • In general, GIRK1 showed the least fluctuation in its levels of expression during development, while dynamic changes were found with the levels of GIRK2 and GIRK3 transcripts [8].
  • Hot-plate paw-lick latencies for wild-type, Kir3.2 knockout, Kir3.3 knockout, and Kir3.4 knockout mice were measured at 52 degrees C and 55 degrees C, following the s.c. injection of either saline or 10 mg/kg morphine [9].
  • We conclude that G protein-gated potassium channels containing Kir3.2 and/or Kir3.3 play a significant role in responses to moderate thermal stimuli [9].
  • On the other hand, mbGIRK2 and mbGIRK3 are more similar to GIRK1 (60%) than to ROMK1 and IRK1 (50%) [10].


  1. Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice. Morgan, A.D., Carroll, M.E., Loth, A.K., Stoffel, M., Wickman, K. Neuropsychopharmacology (2003) [Pubmed]
  2. Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Kofuji, P., Davidson, N., Lester, H.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Axonal sorting of Kir3.3 defines a GABA-containing neuron in the CA3 region of rodent hippocampus. Grosse, G., Eulitz, D., Thiele, T., Pahner, I., Schröter, S., Takamori, S., Grosse, J., Wickman, K., Tapp, R., Veh, R.W., Ottersen, O.P., Ahnert-Hilger, G. Mol. Cell. Neurosci. (2003) [Pubmed]
  4. Structural characterization of the mouse Girk genes. Wickman, K., Pu, W.T., Clapham, D.E. Gene (2002) [Pubmed]
  5. G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. Torrecilla, M., Marker, C.L., Cintora, S.C., Stoffel, M., Williams, J.T., Wickman, K. J. Neurosci. (2002) [Pubmed]
  6. The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype. Hou, P., Yan, S., Tang, W., Nelson, D.J. J. Neurosci. (1999) [Pubmed]
  7. Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.S., Melmed, K., Clark, J.D., Peltz, G., Wickman, K., Mogil, J.S. Pharmacogenet. Genomics (2008) [Pubmed]
  8. Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse. Chen, S.C., Ehrhard, P., Goldowitz, D., Smeyne, R.J. Brain Res. (1997) [Pubmed]
  9. Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice. Marker, C.L., Cintora, S.C., Roman, M.I., Stoffel, M., Wickman, K. Neuroreport (2002) [Pubmed]
  10. Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. Lesage, F., Duprat, F., Fink, M., Guillemare, E., Coppola, T., Lazdunski, M., Hugnot, J.P. FEBS Lett. (1994) [Pubmed]
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