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Gene Review

KCNJ9  -  potassium channel, inwardly rectifying...

Homo sapiens

Synonyms: G protein-activated inward rectifier potassium channel 3, GIRK-3, GIRK3, Inward rectifier K(+) channel Kir3.3, KIR3.3, ...
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Disease relevance of KCNJ9


High impact information on KCNJ9

  • Complexes containing only GIRK2 and GIRK3 could be immunoprecipitated from transfected cells and could be purified from native brain tissue [3].
  • The PEA15 locus is composed of four exons spanning approximately 10.2kb of genomic DNA, flanked upstream by an potentially expressed Alu element, downstream by the H326 gene, and is located within 250kb of KCNJ9 [4].
  • Transcripts for Kir3.3 and Kir3.4 were not detected in the same preparations [5].
  • Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23 [6].
  • High-ranking candidate genes in this susceptibility region include KCNJ9, KCNJ10 and ATP1A2 [7].

Biological context of KCNJ9


Anatomical context of KCNJ9

  • The functional aspects of GIRK3 were reinvestigated by expression in CHO cells [8].
  • However, the homologous mouse brain GIRK3 clone failed to express in the earliest reported functional experiments in Xenopus oocytes [8].


  1. Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3). Vaughn, J., Wolford, J.K., Prochazka, M., Permana, P.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians. Wolford, J.K., Hanson, R.L., Kobes, S., Bogardus, C., Prochazka, M. Mol. Genet. Metab. (2001) [Pubmed]
  3. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. Jelacic, T.M., Kennedy, M.E., Wickman, K., Clapham, D.E. J. Biol. Chem. (2000) [Pubmed]
  4. Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. Wolford, J.K., Bogardus, C., Ossowski, V., Prochazka, M. Gene (2000) [Pubmed]
  5. Kir3.1/3.2 encodes an I(KACh)-like current in gastrointestinal myocytes. Bradley, K.K., Hatton, W.J., Mason, H.S., Walker, R.L., Flynn, E.R., Kenyon, J.L., Horowitz, B. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  6. Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. Lesage, F., Fink, M., Barhanin, J., Lazdunski, M., Mattéi, M.G. Genomics (1995) [Pubmed]
  7. No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy. Lohoff, F.W., Ferraro, T.N., Sander, T., Zhao, H., Dahl, J.P., Berrettini, W.H., Buono, R.J. Neurosci. Lett. (2005) [Pubmed]
  8. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. Jelacic, T.M., Sims, S.M., Clapham, D.E. J. Membr. Biol. (1999) [Pubmed]
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