Gene Review:
Aldh1a2 - aldehyde dehydrogenase family 1, subfamily A2
Mus musculus
Synonyms:
AV116159, Aldehyde dehydrogenase family 1 member A2, Aldh1a7, RALDH 2, RALDH(II), ...
- Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Niederreither, K., McCaffery, P., Dräger, U.C., Chambon, P., Dollé, P. Mech. Dev. (1997)
- Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P., Dollé, P. Development (2001)
- Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. Zhao, D., McCaffery, P., Ivins, K.J., Neve, R.L., Hogan, P., Chin, W.W., Dräger, U.C. Eur. J. Biochem. (1996)
- Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration. Duncan, T., Swint, C., Smith, S.B., Wiggert, B.N. Mol. Vis. (1999)
- Mouse type-2 retinaldehyde dehydrogenase (RALDH2): genomic organization, tissue-dependent expression, chromosome assignment and comparison to other types. Hsu, L.C., Chang, W.C., Yoshida, A. Biochim. Biophys. Acta (2000)
- Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Niederreither, K., Subbarayan, V., Dollé, P., Chambon, P. Nat. Genet. (1999)
- Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Bohnsack, B.L., Lai, L., Dolle, P., Hirschi, K.K. Genes Dev. (2004)
- Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. Molotkov, A., Duester, G. J. Biol. Chem. (2003)
- Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P., Dollé, P. Development (2002)
- Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo. Niederreither, K., Vermot, J., Fraulob, V., Chambon, P., Dolle, P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Niederreither, K., Fraulob, V., Garnier, J.M., Chambon, P., Dollé, P. Mech. Dev. (2002)
- A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Dupé, V., Matt, N., Garnier, J.M., Chambon, P., Mark, M., Ghyselinck, N.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Fan, X., Molotkov, A., Manabe, S., Donmoyer, C.M., Deltour, L., Foglio, M.H., Cuenca, A.E., Blaner, W.S., Lipton, S.A., Duester, G. Mol. Cell. Biol. (2003)
- Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation. Everts, H.B., King, L.E., Sundberg, J.P., Ong, D.E. J. Invest. Dermatol. (2004)
- Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Roberts, C., Ivins, S., Cook, A.C., Baldini, A., Scambler, P.J. Hum. Mol. Genet. (2006)
- Sources and sink of retinoic acid in the embryonic chick retina: distribution of aldehyde dehydrogenase activities, CRABP-I, and sites of retinoic acid inactivation. Mey, J., McCaffery, P., Klemeit, M. Brain Res. Dev. Brain Res. (2001)
- BMP action in skeletogenesis involves attenuation of retinoid signaling. Hoffman, L.M., Garcha, K., Karamboulas, K., Cowan, M.F., Drysdale, L.M., Horton, W.A., Underhill, T.M. J. Cell Biol. (2006)
- Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Matt, N., Dupé, V., Garnier, J.M., Dennefeld, C., Chambon, P., Mark, M., Ghyselinck, N.B. Development (2005)
- Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Martín, M., Gallego-Llamas, J., Ribes, V., Kedinger, M., Niederreither, K., Chambon, P., Dollé, P., Gradwohl, G. Dev. Biol. (2005)
- Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear. Romand, R., Kondo, T., Fraulob, V., Petkovich, M., Dollé, P., Hashino, E. J. Comp. Neurol. (2006)
- RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development. Mic, F.A., Molotkov, A., Fan, X., Cuenca, A.E., Duester, G. Mech. Dev. (2000)
- Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Sirbu, I.O., Gresh, L., Barra, J., Duester, G. Development (2005)
- Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Molotkov, A., Molotkova, N., Duester, G. Dev. Dyn. (2005)
- Complementary domains of retinoic acid production and degradation in the early chick embryo. Swindell, E.C., Thaller, C., Sockanathan, S., Petkovich, M., Jessell, T.M., Eichele, G. Dev. Biol. (1999)
- Hot spots of retinoic acid synthesis in the developing spinal cord. McCaffery, P., Dräger, U.C. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Retinoid signaling and cardiac anteroposterior segmentation. Xavier-Neto, J., Rosenthal, N., Silva, F.A., Matos, T.G., Hochgreb, T., Linhares, V.L. Genesis (2001)
- Pharmacology of RALGA, a mixture of retinaldehyde and glycolic acid. Tran, C., Kasraee, B., Grand, D., Carraux, P., Didierjean, L., Sorg, O., Saurat, J.H. Dermatology (Basel) (2005)