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Gene Review

ALDH1A2  -  aldehyde dehydrogenase 1 family, member A2

Gallus gallus

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High impact information on ALDH1A2

  • Transcripts for all three retinoic acid receptors RaRalpha, RaRbeta and RaRgamma as well as the enzymes involved in RA synthesis, Adh-1 and RALDH-2, RALDH-3, were present in both sympathetic targets and neurons [1].
  • Neural crest cells do not express detectable levels of RALDH-2, but migrating crest cells are associated with RALDH-2 expressing mesoderm [2].
  • We suggest that a gradient of RA within the mesoderm generated by Raldh2 and catabolized by Cyp26C1 could be responsible for patterning the hindbrain [3].
  • RALDH2 immunoreactivity is intense in the choroid, low or absent in the pigment epithelium, and moderate in the neuroepithelium, where it is highest in the outer layers [4].
  • RESULTS: ZENK in the retina and RALDH-2 in the choroid displayed parallel signs of defocus dependent changes in mRNA levels after 15 or 30 min, respectively [5].

Anatomical context of ALDH1A2


Associations of ALDH1A2 with chemical compounds

  • Here we report the immunolocalization of this enzyme (RALDH-2-IR) in stage 6-29 chicken embryos; we also show that tissues that exhibit strong RALDH-2-IR in the embryo contain RALDH-2 and synthesize retinoic acid [2].
  • We have studied in which fundal tissues aldehyde dehydrogenase-2 (AHD2) and retinaldehyde dehydrogenase-2 (RALDH2), enzymes involved in RA synthesis, are expressed and at which levels the effects of vision on RA levels may be controlled [6].


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