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Kcnb2  -  potassium channel, voltage gated Shab...

Rattus norvegicus

Synonyms: CDRK, Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv2.2
 
 
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High impact information on Kcnb2

  • In the brain cdrk mRNA is most concentrated in granule cells of the olfactory bulb and cerebellum [1].
  • Using a cDNA library prepared from circumvallate papillae of rat tongue, we have identified, cloned, and sequenced a novel K+ channel, designated cdrk [1].
  • DRK1 tends to localize to cell bodies and proximal dendrites discretely, while CDRK is diffusely present in cell bodies and is also found on fibers in specific brain areas [2].
  • In the cerebral cortex DRK1 is localized to pyramidal cells, whereas CDRK occurs in small cells, presumably interneurons [2].
 

Analytical, diagnostic and therapeutic context of Kcnb2

References

  1. A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Hwang, P.M., Glatt, C.E., Bredt, D.S., Yellen, G., Snyder, S.H. Neuron (1992) [Pubmed]
  2. Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily. Hwang, P.M., Fotuhi, M., Bredt, D.S., Cunningham, A.M., Snyder, S.H. J. Neurosci. (1993) [Pubmed]
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