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Gene Review

ngb  -  neuroglobin

Danio rerio

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Disease relevance of ngb

  • This observation, firstly, suggests physiological differences of zebrafish eye and brain under hypoxia, and secondly, indicates an important role of neuroglobin in oxidative metabolism, probably oxygen supply within neurons [1].

High impact information on ngb


Biological context of ngb

  • In addition, the neuroglobin gene of T. nigroviridis was sequenced, demonstrating the conservation of the B12.2, E11.0 and G7.0 introns plus the presence of an additional intron in the 5' noncoding region [4].


  1. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). Roesner, A., Hankeln, T., Burmester, T. J. Exp. Biol. (2006) [Pubmed]
  2. Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding. Fuchs, C., Heib, V., Kiger, L., Haberkamp, M., Roesner, A., Schmidt, M., Hamdane, D., Marden, M.C., Hankeln, T., Burmester, T. J. Biol. Chem. (2004) [Pubmed]
  3. Preparation and characterization of a chimeric zebrafish-human neuroglobin engineered by module substitution. Wakasugi, K., Morishima, I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Awenius, C., Hankeln, T., Burmester, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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