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Gene Review

Pxn  -  paxillin

Rattus norvegicus

Synonyms: Paxillin
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Disease relevance of Pxn


High impact information on Pxn


Biological context of Pxn


Anatomical context of Pxn


Associations of Pxn with chemical compounds


Physical interactions of Pxn

  • Whereas previous studies have shown that Crk SH2 binding to paxillin is critical for cell adhesion and migration, our data show that the phosphorylation cycle of c-Crk II determines its dynamic interaction with paxillin, thereby regulating turnover of multiprotein complexes, a critical aspect of cytoskeletal plasticity and actin dynamics [18].
  • Furthermore, immunoprecipitation analysis showed that paxillin forms a heteromeric complex with PLC-gamma1 in cells grown on fibronectin [19].

Enzymatic interactions of Pxn


Regulatory relationships of Pxn


Other interactions of Pxn


Analytical, diagnostic and therapeutic context of Pxn


  1. Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy. Kovacic-Milivojević, B., Roediger, F., Almeida, E.A., Damsky, C.H., Gardner, D.G., Ilić, D. Mol. Biol. Cell (2001) [Pubmed]
  2. Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells. Leduc, I., Meloche, S. J. Biol. Chem. (1995) [Pubmed]
  3. Adhesion-induced tyrosine phosphorylation of the p130 src substrate. Petch, L.A., Bockholt, S.M., Bouton, A., Parsons, J.T., Burridge, K. J. Cell. Sci. (1995) [Pubmed]
  4. Enhanced recovery of injury-caused downregulation of paxillin protein by eNOS gene expression in rat carotid artery. Mechanism of NO inhibition of intimal hyperplasia? Fang, S., Sharma, R.V., Bhalla, R.C. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  5. Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho. García, L.J., Rosado, J.A., González, A., Jensen, R.T. Biochem. J. (1997) [Pubmed]
  6. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Ivankovic-Dikic, I., Grönroos, E., Blaukat, A., Barth, B.U., Dikic, I. Nat. Cell Biol. (2000) [Pubmed]
  7. Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. Nayal, A., Webb, D.J., Brown, C.M., Schaefer, E.M., Vicente-Manzanares, M., Horwitz, A.R. J. Cell Biol. (2006) [Pubmed]
  8. Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. Petit, V., Boyer, B., Lentz, D., Turner, C.E., Thiery, J.P., Vallés, A.M. J. Cell Biol. (2000) [Pubmed]
  9. Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells. Vallés, A.M., Beuvin, M., Boyer, B. J. Biol. Chem. (2004) [Pubmed]
  10. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. Melendez, J., Turner, C., Avraham, H., Steinberg, S.F., Schaefer, E., Sussman, M.A. J. Biol. Chem. (2004) [Pubmed]
  11. Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. Yamakita, Y., Totsukawa, G., Yamashiro, S., Fry, D., Zhang, X., Hanks, S.K., Matsumura, F. J. Cell Biol. (1999) [Pubmed]
  12. Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Altun-Gultekin, Z.F., Chandriani, S., Bougeret, C., Ishizaki, T., Narumiya, S., de Graaf, P., Van Bergen en Henegouwen, P., Hanafusa, H., Wagner, J.A., Birge, R.B. Mol. Cell. Biol. (1998) [Pubmed]
  13. Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells. Li, X., Earp, H.S. J. Biol. Chem. (1997) [Pubmed]
  14. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Taniyama, Y., Weber, D.S., Rocic, P., Hilenski, L., Akers, M.L., Park, J., Hemmings, B.A., Alexander, R.W., Griendling, K.K. Mol. Cell. Biol. (2003) [Pubmed]
  15. Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle. Ohanian, V., Gatfield, K., Ohanian, J. Hypertension (2005) [Pubmed]
  16. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Ishida, M., Marrero, M.B., Schieffer, B., Ishida, T., Bernstein, K.E., Berk, B.C. Circ. Res. (1995) [Pubmed]
  17. Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation? Speert, D.B., Konkle, A.T., Zup, S.L., Schwarz, J.M., Shiroor, C., Taylor, M.E., McCarthy, M.M. Endocrinology (2007) [Pubmed]
  18. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. Escalante, M., Courtney, J., Chin, W.G., Teng, K.K., Kim, J.I., Fajardo, J.E., Mayer, B.J., Hempstead, B.L., Birge, R.B. J. Biol. Chem. (2000) [Pubmed]
  19. Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin. Chang, J.S., Iwashita, S., Lee, Y.H., Kim, M.J., Ryu, S.H., Suh, P.G. FEBS Lett. (1999) [Pubmed]
  20. Syk and paxillin are differentially phosphorylated following adhesion to the plastic substrate in rat alveolar macrophages. Hirano, S., Kanno, S. Immunology (1999) [Pubmed]
  21. Depolarization-induced tyrosine phosphorylation of paxillin in PC12h cells. Khan, M.A., Okumura, N., Okada, M. Eur. J. Biochem. (1996) [Pubmed]
  22. Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components. Koyama, Y., Yoshioka, Y., Hashimoto, H., Matsuda, T., Baba, A. Neuroscience (2000) [Pubmed]
  23. Integrin-mediated signals regulated by members of the rho family of GTPases. Clark, E.A., King, W.G., Brugge, J.S., Symons, M., Hynes, R.O. J. Cell Biol. (1998) [Pubmed]
  24. Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation. Gustavsson, A., Yuan, M., Fällman, M. J. Biol. Chem. (2004) [Pubmed]
  25. Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells. Ribon, V., Saltiel, A.R. J. Biol. Chem. (1996) [Pubmed]
  26. ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. Etienne-Manneville, S., Manneville, J.B., Adamson, P., Wilbourn, B., Greenwood, J., Couraud, P.O. J. Immunol. (2000) [Pubmed]
  27. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. Nikolopoulos, S.N., Turner, C.E. J. Biol. Chem. (2001) [Pubmed]
  28. Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle. Sabri, A., Govindarajan, G., Griffin, T.M., Byron, K.L., Samarel, A.M., Lucchesi, P.A. Circ. Res. (1998) [Pubmed]
  29. Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells. Terfera, D.R., Brown, M.C., Turner, C.E. J. Cell. Physiol. (2002) [Pubmed]
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