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Gene Review

Tln1  -  talin 1

Rattus norvegicus

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Disease relevance of Tln1

  • In addition, approximately half of WF megakaryocytes showed an increased peripheral localization of talin, often associated with membrane blebs, with decreased talin in the cytoplasmic interior [1].
  • At 10 mg/kg, prednisolone markedly suppressed IL-beta and TNF-alpha transcription and calpain mu activation and talin degradation, consistent with the improved 7-day survival after total hepatic ischemia (75% vs. 25% in control group, P = 0.039) [2].
  • Talin and vinculin markedly and diffusely immunostained the neuroma [3].
  • The present study investigated the immunoreactivity of vinculin, talin and paxillin following stab wounds in the cortex and the underlying white matter of adult rats [4].
  • Recent studies have shown significant reduction in the activity of nerve growth factor (NGF) and in the amount of talin cytoskeleton protein immunoreactivity in the perineurium in patients with diabetic neuropathy [5].

High impact information on Tln1


Biological context of Tln1

  • In the presence of TPA (24 and 48 h exposure) the level of colocalization of both talin and phosphoserine residues was the same in the treated cells and in the control cells, but the level of talin phosphorylation was higher in the treated cells [11].
  • We also demonstrated that the expression of talin during satellite cell differentiation was constant in both the control and TPA-treated cells [11].
  • Increased talin-membrane interaction may be implicated in DA-induced maintenance of a round phenotype in lactotrope cells [12].
  • Cell detachment was preceded by a complete loss of the alpha-actinin binding protein talin from the focal adhesions, which was directly associated with F-actin disorganization [13].

Anatomical context of Tln1


Associations of Tln1 with chemical compounds

  • We demonstrated that there is a colocalization of talin and phosphoserine residues during the differentiation of satellite cells, and that it changes after TPA (a protein kinase C activator) treatment, and showed that talin existing in the cell-extracellular matrix and cell-cell contact area was not phosphorylated [11].
  • Activation of calcium-dependent proteases during Triton X-100 extraction caused conversion of the 235-Kd antigen into a major fragment of 200 Kd and minor fragments ranging to 115 Kd, identical in mobility to fragments of rat platelet talin produced in the same samples [1].
  • Nitric-oxide synthase is a mechanical signal transducer that modulates talin and vinculin expression [15].
  • When screening for proteins present in the distal filopodial phosphotyrosine complexes of beta1B cells, p130Cas and the filopodia proteins vasodilator-stimulated phosphoprotein and talin were found, whereas the typical focal complex proteins focal adhesion kinase, paxillin, and vinculin were not [16].
  • Other muscle proteins were also present within electrocytes: Actin and sarcomeric alpha-actinin were found within the subsynaptic membrane beneath the plasmalemma of the electrocytes, and talin and acetylcholine receptors were detected both at the innervated posterior face and at the non-innervated anterior face [17].

Enzymatic interactions of Tln1


Other interactions of Tln1

  • During the transformation of HSC to myofibroblasts, LAP and LTBP become strongly colocalized with other components of the cytoskeletal network like smooth muscle--actin, desmin, and talin [19].
  • Within the peripheral FA, Keap1 was present in distinct foci along the length of the FA and these foci were different from vinculin, talin, paxillin, and phospho-tyrosine rich regions of the FA [20].
  • Biochemical analysis has shown a correlation between tyrosine-specific phosphorylation of the fibronectin receptor and the loss of surface-bound fibronectin, but no such correlation with phosphorylation of vinculin or talin [21].
  • Dp116, talin, vinculin and vimentin immunoreactivities following nerve transection [3].
  • In this study, immunoblot analysis was used to study the expression of N-cadherin, alpha-catenin, beta-catenin, vinculin, talin, and laminin in rat cardiac muscles at embryonic days 15 and 19, the day of birth (postnatal day 0), postnatal weeks 1, 2, 3, and 4, and in the adult [22].

Analytical, diagnostic and therapeutic context of Tln1


  1. A unique talin antigenic determinant and anomalous megakaryocyte talin distribution associated with abnormal platelet formation in the Wistar Furth rat. Jackson, C.W., Hutson, N.K., Steward, S.A., Stenberg, P.E. Blood (1992) [Pubmed]
  2. Prednisolone suppresses ischemia-reperfusion injury of the rat liver by reducing cytokine production and calpain mu activation. Wang, M., Sakon, M., Umeshita, K., Okuyama, M., Shiozaki, K., Nagano, H., Dohno, K., Nakamori, S., Monden, M. J. Hepatol. (2001) [Pubmed]
  3. Dp116, talin, vinculin and vimentin immunoreactivities following nerve transection. Vita, G., Mazzeo, A., Muglia, U., Girlanda, P., Toscano, A., Rodolico, C., Migliorato, A. Neuroreport (1998) [Pubmed]
  4. Immunohistochemical investigation of actin-anchoring proteins vinculin, talin and paxillin in rat brain following lesion: a moderate reaction, confined to the astroglia of brain tracts. Kálmán, M., Szabó, A. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2001) [Pubmed]
  5. Talin immunogold density increases in sciatic nerve of diabetic rats after nerve growth factor treatment. Renno, W.M., Saleh, F., Klepacek, I., Al-Awadi, F. Medicina (Kaunas, Lithuania) (2006) [Pubmed]
  6. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Miyoshi, H., Umeshita, K., Sakon, M., Imajoh-Ohmi, S., Fujitani, K., Gotoh, M., Oiki, E., Kambayashi, J., Monden, M. Gastroenterology (1996) [Pubmed]
  7. Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3,4,5)-p(3) binding to alpha-actinin. Greenwood, J.A., Theibert, A.B., Prestwich, G.D., Murphy-Ullrich, J.E. J. Cell Biol. (2000) [Pubmed]
  8. Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. Jaken, S., Leach, K., Klauck, T. J. Cell Biol. (1989) [Pubmed]
  9. Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells. Müller, M.M., Singer, B.B., Klaile, E., Obrink, B., Lucka, L. Blood (2005) [Pubmed]
  10. Abnormal subcellular distribution of myosin and talin in Wistar Furth rat platelets. Pestina, T.I., Jackson, C.W., Stenberg, P.E. Blood (1995) [Pubmed]
  11. Talin distribution during the differentiation of satellite cells isolated from rat skeletal muscle. Brzóska, E., Wróbel, E., Grabowska, I., Moraczewski, J. Cell. Mol. Biol. Lett. (2004) [Pubmed]
  12. Intracellular mechanisms involved in dopamine-induced actin cytoskeleton organization and maintenance of a round phenotype in cultured rat lactotrope cells. Nguyen, B., Carbajal, M.E., Vitale, M.L. Endocrinology (1999) [Pubmed]
  13. In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function. Van de Water, B., Jaspers, J.J., Maasdam, D.H., Mulder, G.J., Nagelkerke, J.F. Am. J. Physiol. (1994) [Pubmed]
  14. Hydrostatic pressure has different effects on the assembly of tubulin, actin, myosin II, vinculin, talin, vimentin, and cytokeratin in mammalian tissue cells. Crenshaw, H.C., Allen, J.A., Skeen, V., Harris, A., Salmon, E.D. Exp. Cell Res. (1996) [Pubmed]
  15. Nitric-oxide synthase is a mechanical signal transducer that modulates talin and vinculin expression. Tidball, J.G., Spencer, M.J., Wehling, M., Lavergne, E. J. Biol. Chem. (1999) [Pubmed]
  16. Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation. Gustavsson, A., Yuan, M., Fällman, M. J. Biol. Chem. (2004) [Pubmed]
  17. Differential expression of proteins in muscle and electric organ, a muscle derivative. Patterson, J.M., Zakon, H.H. J. Comp. Neurol. (1996) [Pubmed]
  18. Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. Bockholt, S.M., Burridge, K. J. Biol. Chem. (1993) [Pubmed]
  19. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn, S., Kühl, K., Gressner, A.M. Hepatology (1998) [Pubmed]
  20. Keap1 in adhesion complexes. Velichkova, M., Hasson, T. Cell Motil. Cytoskeleton (2003) [Pubmed]
  21. The interaction of the tyrosine kinase pp60src with membrane and cytoskeletal components. Kellie, S., Horvath, A.R., Felice, G., Anand, R., Murphy, C., Westwick, J. Symp. Soc. Exp. Biol. (1993) [Pubmed]
  22. Role of N-cadherin- and integrin-based costameres in the development of rat cardiomyocytes. Wu, J.C., Sung, H.C., Chung, T.H., DePhilip, R.M. J. Cell. Biochem. (2002) [Pubmed]
  23. Localization of actin, beta-spectrin, 43 x 10(3) Mr and 58 x 10(3) Mr proteins to receptor-enriched domains of newly formed acetylcholine receptor aggregates in isolated myotube membranes. Daniels, M.P. J. Cell. Sci. (1990) [Pubmed]
  24. Colonization of ion-modified polyethylene with vascular smooth muscle cells in vitro. Walachová, K., Svorcík, V., Bacáková, L., Hnatowicz, V. Biomaterials (2002) [Pubmed]
  25. Determination of a safe vascular clamping method for liver surgery: evaluation by measuring activation of calpain mu. Wang, M., Sakon, M., Umeshita, K., Miyoshi, H., Taniguchi, K., Kishimoto, S., Imajoh-Ohmi, S., Monden, M. Archives of surgery (Chicago, Ill. : 1960) (1998) [Pubmed]
  26. Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions. Frenette, J., Tidball, J.G. Am. J. Physiol. (1998) [Pubmed]
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