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Bhmt  -  betaine-homocysteine methyltransferase

Mus musculus

Synonyms: Betaine--homocysteine S-methyltransferase 1
 
 
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Disease relevance of Bhmt

 

High impact information on Bhmt

 

Analytical, diagnostic and therapeutic context of Bhmt

  • Immunoblotting confirmed the presence of BHMT on the canalicular membrane, failed to reveal the presence of the second enzyme in this pathway, methionine adenosyltransferase, and localized the third enzyme of the pathway, PE N-methyltransferase (PEMT) [5].

References

  1. Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. Collinsova, M., Strakova, J., Jiracek, J., Garrow, T.A. J. Nutr. (2006) [Pubmed]
  2. S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. Jiracek, J., Collinsova, M., Rosenberg, I., Budesinsky, M., Protivinska, E., Netusilova, H., Garrow, T.A. J. Med. Chem. (2006) [Pubmed]
  3. Isolation and characterization of a mouse betaine-homocysteine S-methyltransferase gene and pseudogene. Neece, D.J., Griffiths, M.A., Garrow, T.A. Gene (2000) [Pubmed]
  4. Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. Fisher, M.C., Zeisel, S.H., Mar, M.H., Sadler, T.W. FASEB J. (2002) [Pubmed]
  5. Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. Sehayek, E., Wang, R., Ono, J.G., Zinchuk, V.S., Duncan, E.M., Shefer, S., Vance, D.E., Ananthanarayanan, M., Chait, B.T., Breslow, J.L. J. Lipid Res. (2003) [Pubmed]
 
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