Gene Review:
Pemt - phosphatidylethanolamine N-methyltransferase
Mus musculus
Synonyms:
PEAMT, PEMT, PEMT2, Pempt, Pempt2, ...
- Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet. Waite, K.A., Vance, D.E. Biochim. Biophys. Acta (2004)
- An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. Noga, A.A., Zhao, Y., Vance, D.E. J. Biol. Chem. (2002)
- Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. Watkins, S.M., Zhu, X., Zeisel, S.H. J. Nutr. (2003)
- Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase. Walkey, C.J., Donohue, L.R., Bronson, R., Agellon, L.B., Vance, D.E. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The unique acyl chain specificity of biliary phosphatidylcholines in mice is independent of their biosynthetic origin in the liver. Agellon, L.B., Walkey, C.J., Vance, D.E., Kuipers, F., Verkade, H.J. Hepatology (1999)
- Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. Jacobs, R.L., Stead, L.M., Devlin, C., Tabas, I., Brosnan, M.E., Brosnan, J.T., Vance, D.E. J. Biol. Chem. (2005)
- Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. Dobrzyn, A., Dobrzyn, P., Miyazaki, M., Sampath, H., Chu, K., Ntambi, J.M. J. Biol. Chem. (2005)
- Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus. Zhu, X., Mar, M.H., Song, J., Zeisel, S.H. Brain Res. Dev. Brain Res. (2004)
- Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. Igolnikov, A.C., Green, R.M. J. Hepatol. (2006)
- Involvement of mitochondrial contact sites in the subcellular compartmentalization of phospholipid biosynthetic enzymes. Ardail, D., Gasnier, F., Lermé, F., Simonot, C., Louisot, P., Gateau-Roesch, O. J. Biol. Chem. (1993)
- A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. Noga, A.A., Vance, D.E. J. Biol. Chem. (2003)
- A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase. Robichaud, J.C., Francis, G.A., Vance, D.E. J. Biol. Chem. (2008)
- Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. Jacobs, R.L., Devlin, C., Tabas, I., Vance, D.E. J. Biol. Chem. (2004)
- Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice. Zhu, X., Zeisel, S.H. Brain Res. Mol. Brain Res. (2005)
- Methyl balance and transmethylation fluxes in humans. Mudd, S.H., Brosnan, J.T., Brosnan, M.E., Jacobs, R.L., Stabler, S.P., Allen, R.H., Vance, D.E., Wagner, C. Am. J. Clin. Nutr. (2007)
- Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. Zhu, X., Song, J., Mar, M.H., Edwards, L.J., Zeisel, S.H. Biochem. J. (2003)
- Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. Sehayek, E., Wang, R., Ono, J.G., Zinchuk, V.S., Duncan, E.M., Shefer, S., Vance, D.E., Ananthanarayanan, M., Chait, B.T., Breslow, J.L. J. Lipid Res. (2003)