The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hyperhomocysteinemia


Psychiatry related information on Hyperhomocysteinemia


High impact information on Hyperhomocysteinemia


Chemical compound and disease context of Hyperhomocysteinemia


Biological context of Hyperhomocysteinemia


Anatomical context of Hyperhomocysteinemia


Gene context of Hyperhomocysteinemia


Analytical, diagnostic and therapeutic context of Hyperhomocysteinemia


  1. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Ji, C., Kaplowitz, N. Gastroenterology (2003) [Pubmed]
  2. Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Robert, K., Nehmé, J., Bourdon, E., Pivert, G., Friguet, B., Delcayre, C., Delabar, J.M., Janel, N. Gastroenterology (2005) [Pubmed]
  3. Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Hussein, W.I., Green, R., Jacobsen, D.W., Faiman, C. Ann. Intern. Med. (1999) [Pubmed]
  4. The atherogenic effect of excess methionine intake. Troen, A.M., Lutgens, E., Smith, D.E., Rosenberg, I.H., Selhub, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Isotalo, P.A., Wells, G.A., Donnelly, J.G. Am. J. Hum. Genet. (2000) [Pubmed]
  6. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Tiemeier, H., van Tuijl, H.R., Hofman, A., Meijer, J., Kiliaan, A.J., Breteler, M.M. The American journal of psychiatry. (2002) [Pubmed]
  7. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., Licastro, F. Am. J. Clin. Nutr. (2005) [Pubmed]
  8. Folic acid. Donnelly, J.G. Critical reviews in clinical laboratory sciences. (2001) [Pubmed]
  9. Sleep deprivation reduces total plasma homocysteine levels in rats. de Oliveira, A.C., D'Almeida, V., Hipólide, D.C., Nobrega, J.N., Tufik, S. Can. J. Physiol. Pharmacol. (2002) [Pubmed]
  10. Prevention of strokes. Jeerakathil, T.J., Wolf, P.A. Current atherosclerosis reports. (2001) [Pubmed]
  11. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. Nappo, F., De Rosa, N., Marfella, R., De Lucia, D., Ingrosso, D., Perna, A.F., Farzati, B., Giugliano, D. JAMA (1999) [Pubmed]
  12. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Rimm, E.B., Willett, W.C., Hu, F.B., Sampson, L., Colditz, G.A., Manson, J.E., Hennekens, C., Stampfer, M.J. JAMA (1998) [Pubmed]
  13. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. Werstuck, G.H., Lentz, S.R., Dayal, S., Hossain, G.S., Sood, S.K., Shi, Y.Y., Zhou, J., Maeda, N., Krisans, S.K., Malinow, M.R., Austin, R.C. J. Clin. Invest. (2001) [Pubmed]
  14. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. Eberhardt, R.T., Forgione, M.A., Cap, A., Leopold, J.A., Rudd, M.A., Trolliet, M., Heydrick, S., Stark, R., Klings, E.S., Moldovan, N.I., Yaghoubi, M., Goldschmidt-Clermont, P.J., Farber, H.W., Cohen, R., Loscalzo, J. J. Clin. Invest. (2000) [Pubmed]
  15. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study. Guttormsen, A.B., Ueland, P.M., Nesthus, I., Nygård, O., Schneede, J., Vollset, S.E., Refsum, H. J. Clin. Invest. (1996) [Pubmed]
  16. Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations. Kang, S.S., Wong, P.W., Bock, H.G., Horwitz, A., Grix, A. Am. J. Hum. Genet. (1991) [Pubmed]
  17. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Chambers, J.C., McGregor, A., Jean-Marie, J., Obeid, O.A., Kooner, J.S. Circulation (1999) [Pubmed]
  18. Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Devlin, A.M., Arning, E., Bottiglieri, T., Faraci, F.M., Rozen, R., Lentz, S.R. Blood (2004) [Pubmed]
  19. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Chen, Z., Karaplis, A.C., Ackerman, S.L., Pogribny, I.P., Melnyk, S., Lussier-Cacan, S., Chen, M.F., Pai, A., John, S.W., Smith, R.S., Bottiglieri, T., Bagley, P., Selhub, J., Rudnicki, M.A., James, S.J., Rozen, R. Hum. Mol. Genet. (2001) [Pubmed]
  20. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Devlin, A.M., Ling, E.H., Peerson, J.M., Fernando, S., Clarke, R., Smith, A.D., Halsted, C.H. Hum. Mol. Genet. (2000) [Pubmed]
  21. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. Durand, P., Lussier-Cacan, S., Blache, D. FASEB J. (1997) [Pubmed]
  22. Altered gene expression in liver from a murine model of hyperhomocysteinemia. Robert, K., Chassé, J.F., Santiard-Baron, D., Vayssettes, C., Chabli, A., Aupetit, J., Maeda, N., Kamoun, P., London, J., Janel, N. J. Biol. Chem. (2003) [Pubmed]
  23. Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary stenting. Kosokabe, T., Okumura, K., Sone, T., Kondo, J., Tsuboi, H., Mukawa, H., Tomida, T., Suzuki, T., Kamiya, H., Matsui, H., Hayakawa, T. Circulation (2001) [Pubmed]
  24. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Woo, K.S., Chook, P., Lolin, Y.I., Cheung, A.S., Chan, L.T., Sun, Y.Y., Sanderson, J.E., Metreweli, C., Celermajer, D.S. Circulation (1997) [Pubmed]
  25. Evidence of carotid artery wall hypertrophy in homozygous homocystinuria. Megnien, J.L., Gariepy, J., Saudubray, J.M., Nuoffer, J.M., Denarie, N., Levenson, J., Simon, A. Circulation (1998) [Pubmed]
  26. Hyperhomocysteinemia in cerebral vein thrombosis. Martinelli, I., Battaglioli, T., Pedotti, P., Cattaneo, M., Mannucci, P.M. Blood (2003) [Pubmed]
  27. Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences. Perna, A.F., Ingrosso, D., Satta, E., Lombardi, C., Galletti, P., D'Aniello, A., De Santo, N.G. J. Am. Soc. Nephrol. (2004) [Pubmed]
  28. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR. Goyette, P., Christensen, B., Rosenblatt, D.S., Rozen, R. Am. J. Hum. Genet. (1996) [Pubmed]
  29. Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis. Kluijtmans, L.A., Boers, G.H., Verbruggen, B., Trijbels, F.J., Novakova, I.R., Blom, H.J. Blood (1998) [Pubmed]
  30. Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism. Wilson, A., Leclerc, D., Rosenblatt, D.S., Gravel, R.A. Hum. Mol. Genet. (1999) [Pubmed]
  31. Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. Devlin, A.M., Bottiglieri, T., Domann, F.E., Lentz, S.R. J. Biol. Chem. (2005) [Pubmed]
  32. Effect of hyperhomocysteinemia on protein C activation and activity. Lentz, S.R., Piegors, D.J., Fernández, J.A., Erger, R.A., Arning, E., Malinow, M.R., Griffin, J.H., Bottiglieri, T., Haynes, W.G., Heistad, D.D. Blood (2002) [Pubmed]
  33. Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna multicenter study. Sunder-Plassmann, G., Födinger, M., Buchmayer, H., Papagiannopoulos, M., Wojcik, J., Kletzmayr, J., Enzenberger, B., Janata, O., Winkelmayer, W.C., Paul, G., Auinger, M., Barnas, U., Hörl, W.H. J. Am. Soc. Nephrol. (2000) [Pubmed]
  34. Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease. Willems, F.F., Aengevaeren, W.R., Boers, G.H., Blom, H.J., Verheugt, F.W. J. Am. Coll. Cardiol. (2002) [Pubmed]
  35. Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients. Bostom, A.G., Gohh, R.Y., Tsai, M.Y., Hopkins-Garcia, B.J., Nadeau, M.R., Bianchi, L.A., Jacques, P.F., Rosenberg, I.H., Selhub, J. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  36. Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia. Ungvari, Z., Pacher, P., Rischák, K., Szollár, L., Koller, A. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
WikiGenes - Universities