The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Bhmt  -  betaine-homocysteine S-methyltransferase

Rattus norvegicus

Synonyms: Betaine--homocysteine S-methyltransferase 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bhmt


High impact information on Bhmt


Biological context of Bhmt


Anatomical context of Bhmt


Associations of Bhmt with chemical compounds


Other interactions of Bhmt


Analytical, diagnostic and therapeutic context of Bhmt


  1. Betaine homocysteine methyltransferase: gene cloning and expression analysis in rat liver cirrhosis. Forestier, M., Bänninger, R., Reichen, J., Solioz, M. Biochim. Biophys. Acta (2003) [Pubmed]
  2. Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Sparks, J.D., Collins, H.L., Chirieac, D.V., Cianci, J., Jokinen, J., Sowden, M.P., Galloway, C.A., Sparks, C.E. Biochem. J. (2006) [Pubmed]
  3. Betaine analogues alter homocysteine metabolism in rats. Slow, S., Lever, M., Lee, M.B., George, P.M., Chambers, S.T. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  4. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. Nieman, K.M., Rowling, M.J., Garrow, T.A., Schalinske, K.L. J. Biol. Chem. (2004) [Pubmed]
  5. Autolysosomal membrane-associated betaine homocysteine methyltransferase. Limited degradation fragment of a sequestered cytosolic enzyme monitoring autophagy. Ueno, T., Ishidoh, K., Mineki, R., Tanida, I., Murayama, K., Kadowaki, M., Kominami, E. J. Biol. Chem. (1999) [Pubmed]
  6. Methionine metabolism in mammals. Adaptation to methionine excess. Finkelstein, J.D., Martin, J.J. J. Biol. Chem. (1986) [Pubmed]
  7. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. Finkelstein, J.D., Martin, J.J. J. Biol. Chem. (1984) [Pubmed]
  8. Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase. González, B., Campillo, N., Garrido, F., Gasset, M., Sanz-Aparicio, J., Pajares, M.A. Biochem. J. (2003) [Pubmed]
  9. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. Kharbanda, K.K., Mailliard, M.E., Baldwin, C.R., Beckenhauer, H.C., Sorrell, M.F., Tuma, D.J. J. Hepatol. (2007) [Pubmed]
  10. Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Kharbanda, K.K., Rogers, D.D., Mailliard, M.E., Siford, G.L., Barak, A.J., Beckenhauer, H.C., Sorrell, M.F., Tuma, D.J. Biochem. Pharmacol. (2005) [Pubmed]
  11. Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats. Davis, C.D., Uthus, E.O. J. Nutr. (2003) [Pubmed]
  12. Association of betaine-homocysteine S-methyltransferase with microtubules. Sandu, C., Nick, P., Hess, D., Schiltz, E., Garrow, T.A., Brandsch, R. Biol. Chem. (2000) [Pubmed]
  13. Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes. Furuya, N., Kanazawa, T., Fujimura, S., Ueno, T., Kominami, E., Kadowaki, M. J. Biochem. (2001) [Pubmed]
  14. Comparative studies on the methionine synthesis in sheep and rat tissues. Xue, G.P., Snoswell, A.M. Comp. Biochem. Physiol., B (1985) [Pubmed]
  15. Rat liver betaine-homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions. Garrido, F., Gasset, M., Sanz-Aparicio, J., Alfonso, C., Pajares, M.A. Biochem. J. (2005) [Pubmed]
  16. Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine. Finkelstein, J.D., Martin, J.J., Harris, B.J., Kyle, W.E. J. Nutr. (1983) [Pubmed]
  17. Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase. Sowden, M.P., Collins, H.L., Smith, H.C., Garrow, T.A., Sparks, J.D., Sparks, C.E. Biochem. J. (1999) [Pubmed]
  18. Crystallization and preliminary X-ray study of recombinant betaine-homocysteine S-methyltransferase from rat liver. González, B., Pajares, M.A., Too, H.P., Garrido, F., Blundell, T.L., Sanz-Aparicio, J. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  19. A nuclear-magnetic-resonance-based assay for betaine-homocysteine methyltransferase activity. Lee, M.B., Blunt, J.W., Lever, M., George, P.M. Anal. Biochem. (2004) [Pubmed]
WikiGenes - Universities