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Gene Review

iaaM  -  hypothetical protein

Agrobacterium tumefaciens

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Disease relevance of iaaM

  • The rate-limiting bacterial IAA-biosynthetic gene iaaM and the reporter gene for beta-glucuronidase (GUS), uidA, were each fused to the cambial-region-specific Agrobacterium rhizogenes rolC promoter and linked on the same T-DNA [1].
  • The construct consists of the DefH9 promoter from Antirrhinum majus and the iaaM coding sequence from Pseudomonas syringae [2].

High impact information on iaaM

  • Moreover, quantitative fluorometric analysis of GUS activity allowed estimation of the level of de novo production of IAA in transgenic lines carrying a single-copy insert of the iaaM, uidA T-DNA [1].
  • In situ hybridization of the iaaM gene confirmed that histochemical analysis of GUS activity could be used to predict iaaM gene expression [1].
  • Whereas iaaM genes encode flavin adenine dinucleotide (FAD)-dependent tryptophan 2-monooxygenases that catalyze the synthesis of indole-3-acetamide (IAM), A4-orf8 from Agrobacterium rhizogenes A4 does not [3].
  • The MAT vector system is designed to use the oncogenes (ipt, iaaM/H, rol) of Agrobacterium, which control the endogenous levels of plant hormones and the cell responses to plant growth regulators, to differentiate transgenic cells, and to select marker-free transgenic plants [4].


  1. Cambial-region-specific expression of the Agrobacterium iaa genes in transgenic aspen visualized by a linked uidA reporter gene. Tuominen, H., Puech, L., Regan, S., Fink, S., Olsson, O., Sundberg, B. Plant Physiol. (2000) [Pubmed]
  2. The DefH9-iaaM-containing construct efficiently induces parthenocarpy in cucumber. Yin, Z., Malinowski, R., Ziółkowska, A., Sommer, H., Plcader, W., Malepszy, S. Cell. Mol. Biol. Lett. (2006) [Pubmed]
  3. The T-DNA oncogene A4-orf8 from Agrobacterium rhizogenes A4 induces abnormal growth in tobacco. Umber, M., Clément, B., Otten, L. Mol. Plant Microbe Interact. (2005) [Pubmed]
  4. Elimination of marker genes from transgenic plants using MAT vector systems. Ebinuma, H., Sugita, K., Endo, S., Matsunaga, E., Yamada, K. Methods Mol. Biol. (2005) [Pubmed]
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