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Gene Review

virF  -  hypothetical protein

Agrobacterium tumefaciens

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Disease relevance of virF


High impact information on virF


Chemical compound and disease context of virF


Biological context of virF

  • This difference is due to the absence of a functional virF locus, which is necessary for efficient tumorigenesis on N. glauca, from the nopaline Ti plasmids [1].
  • Genetic studies and DNA sequence analysis of the virF locus revealed that virF embraces one open reading frame coding for a hydrophilic protein with a molecular mass of 22,437 Da [1].
  • However, mutations in the virF locus rendered the octopine strain agroinfectious on maize, whereas such virF-defective octopine strains, when complemented by virF on a plasmid, completely lost their agroinfectivity [4].

Other interactions of virF

  • Here, we report that double mutation of virF and virE3 leads to strongly diminished tumor formation on tobacco, tomato and sunflower [5].


  1. Octopine and nopaline strains of Agrobacterium tumefaciens differ in virulence; molecular characterization of the virF locus. Melchers, L.S., Maroney, M.J., den Dulk-Ras, A., Thompson, D.V., van Vuuren, H.A., Schilperoort, R.A., Hooykaas, P.J. Plant Mol. Biol. (1990) [Pubmed]
  2. Transgenic N. glauca plants expressing bacterial virulence gene virF are converted into hosts for nopaline strains of A. tumefaciens. Regensburg-Tuïnk, A.J., Hooykaas, P.J. Nature (1993) [Pubmed]
  3. The presence and characterization of a virF gene on Agrobacterium vitis Ti plasmids. Schrammeijer, B., Hemelaar, J., Hooykaas, P.J. Mol. Plant Microbe Interact. (1998) [Pubmed]
  4. virF, the host-range-determining virulence gene of Agrobacterium tumefaciens, affects T-DNA transfer to Zea mays. Jarchow, E., Grimsley, N.H., Hohn, B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. The Agrobacterium VirE3 effector protein: a potential plant transcriptional activator. Garc??a-Rodr??guez, F.M., Schrammeijer, B., Hooykaas, P.J. Nucleic Acids Res. (2006) [Pubmed]
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