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Chemical Compound Review

Cucumopine     2-(2-carboxyethyl)-3,7,9...

Synonyms: Mikimopine, AGN-PC-000V4G, AG-K-99797, ACMC-20md9d, ACMC-20mou2, ...
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Disease relevance of Mikimopine


High impact information on Mikimopine


Chemical compound and disease context of Mikimopine


Biological context of Mikimopine

  • The mis homolog was also found in the genome of three other Nicotiana species: N. tomentosa, N. tomentosiformis, and N. tabacum; however, the site of insertion differed from that in N. glauca, suggesting that A. rhizogenes harboring mikimopine-type pRi independently infected the ancestors of some Nicotiana plants [1].
  • Several constructs in which different lengths of pRi8196 right-border region were linked to the cucumopine synthesis gene on an Agrobacterium-Escherichia coli shuttle vector were made [9].
  • Two other octopine/cucumopine strains carry an IS870 copy on their chromosome (IS870.3) [10].
  • The ubiquitous grapevine-associated octopine/cucumopine Ti plasmids of biotype III Agrobacterium tumefaciens strains carry two T regions, TA and TB, with a complex oncogene arrangement [11].
  • The coding region of trolC is similar in sequence (69-87% for DNA and 54-89% for the deduced amino acid sequence) to rolC genes of the agropine, mannopine, and mikimopine strains of Ri-plasmids and the N. glauca rolC homologue [12].

Associations of Mikimopine with other chemical compounds


Gene context of Mikimopine

  • PCR-RFLP analysis of the T-DNA and virD2 regions showed sequence homology between all cucumopine pRi, indicating that these pRi are monomorphic, and thus this pRi remained in the UK without inducing symptoms for some 15 years between outbreaks in the 1970s and 1990s [2].
  • Cucumopine pRi were also shown to possess the virE2 substitute GALLS gene by Southern blotting [2].

Analytical, diagnostic and therapeutic context of Mikimopine


  1. Tobacco plants were transformed by Agrobacterium rhizogenes infection during their evolution. Suzuki, K., Yamashita, I., Tanaka, N. Plant J. (2002) [Pubmed]
  2. Recurrent outbreaks of root mat in cucumber and tomato are associated with a monomorphic, cucumopine, Ri-plasmid harboured by various Alphaproteobacteria. Weller, S.A., Stead, D.E., Young, J.P. FEMS Microbiol. Lett. (2006) [Pubmed]
  3. The complete nucleotide sequence of a plant root-inducing (Ri) plasmid indicates its chimeric structure and evolutionary relationship between tumor-inducing (Ti) and symbiotic (Sym) plasmids in Rhizobiaceae. Moriguchi, K., Maeda, Y., Satou, M., Hardayani, N.S., Kataoka, M., Tanaka, N., Yoshida, K. J. Mol. Biol. (2001) [Pubmed]
  4. Root-inducing region of mikimopine type Ri plasmid pRi1724. Kiyokawa, S., Kobayashi, K., Kikuchi, Y., Kamada, H., Harada, H. Plant Physiol. (1994) [Pubmed]
  5. Mikimopine synthase (mis) gene on pRi1724. Suzuki, K., Tanaka, N., Kamada, H., Yamashita, I. Gene (2001) [Pubmed]
  6. High-efficiency induction of soybean hairy roots and propagation of the soybean cyst nematode. Cho, H.J., Farrand, S.K., Noel, G.R., Widholm, J.M. Planta (2000) [Pubmed]
  7. Natural instability of Agrobacterium vitis Ti plasmid due to unusual duplication of a 2.3-kb DNA fragment. Fournier, P., de Ruffray, P., Otten, L. Mol. Plant Microbe Interact. (1994) [Pubmed]
  8. The presence and characterization of a virF gene on Agrobacterium vitis Ti plasmids. Schrammeijer, B., Hemelaar, J., Hooykaas, P.J. Mol. Plant Microbe Interact. (1998) [Pubmed]
  9. A T-DNA transfer stimulator sequence in the vicinity of the right border of pRi8196. Hansen, G., Tempé, J., Brevet, J. Plant Mol. Biol. (1992) [Pubmed]
  10. IS870 requires a 5'-CTAG-3' target sequence to generate the stop codon for its large ORF1. Fournier, P., Paulus, F., Otten, L. J. Bacteriol. (1993) [Pubmed]
  11. Functional analysis of a complex oncogene arrangement in biotype III Agrobacterium tumefaciens strains. Huss, B., Tinland, B., Paulus, F., Walter, B., Otten, L. Plant Mol. Biol. (1990) [Pubmed]
  12. Horizontal gene transfer: regulated expression of a tobacco homologue of the Agrobacterium rhizogenes rolC gene. Meyer, A.D., Ichikawa, T., Meins, F. Mol. Gen. Genet. (1995) [Pubmed]
  13. Agrobacterium vitis nopaline Ti plasmid pTiAB4: relationship to other Ti plasmids and T-DNA structure. Otten, L., De Ruffray, P. Mol. Gen. Genet. (1994) [Pubmed]
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