Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CYCSP1 - cytochrome c, somatic pseudogene 1

Homo sapiens

Synonyms: HC5, HCP36

Houlihan, A.J. et al., Brock, T.C. et al., Maltby, L. et al., van der Hoeven, N.

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Disease relevance of CYCSP1

In the enclosure study, indirect effects of metribuzin on invertebrate populations were observed at an exposure concentration that was approximately 20 times lower than the corresponding HC5 value based on lab toxicity data for aquatic invertebrates [1].
Bovicin HC5, a lantibiotic produced by Streptococcus bovis HC5, has the ability to inhibit nisin-resistant bacteria [2].
These results indicate that nisin and bovicin HC5 react differently with the cell surfaces of Gram-positive bacteria [2].

High impact information on CYCSP1

The Effect of Calcium and Magnesium on the Activity of Bovicin HC5 and Nisin [2].
The sensitivity distributions of freshwater arthropods were similar for both field and laboratory exposure, and the lower HC5 (95% protection with 95% confidence) estimate was protective of adverse ecological effects in freshwater ecosystems [3].
A comparison of the risk assessment procedures reveals that the first-tier approach is the most conservative for metamitron and metribuzin, and that HC5 values (and even HC10 values) based on acute EC50 values of algae and aquatic vascular plants may be used to derive maximum permissible concentrations for single applications [1].
The non-parametric HC5 and HC5(0.05) estimation is illustrated with an example of sensitivity data on malathion [4].

References

Comparing aquatic risk assessment methods for the photosynthesis-inhibiting herbicides metribuzin and metamitron. Brock, T.C., Crum, S.J., Deneer, J.W., Heimbach, F., Roijackers, R.M., Sinkeldam, J.A. Environ. Pollut. (2004) [Pubmed]
The Effect of Calcium and Magnesium on the Activity of Bovicin HC5 and Nisin. Houlihan, A.J., Russell, J.B. Curr. Microbiol. (2006) [Pubmed]
Insecticide species sensitivity distributions: importance of test species selection and relevance to aquatic ecosystems. Maltby, L., Blake, N., Brock, T.C., van den Brink, P.J. Environ. Toxicol. Chem. (2005) [Pubmed]
Estimating the 5-percentile of the species sensitivity distributions without any assumptions about the distribution. van der Hoeven, N. Ecotoxicology (2001) [Pubmed]

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