Disease relevance of magnesium

• The second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2) examined the effect of an intravenous regimen of magnesium sulphate in 2316 patients with suspected acute myocardial infarction [1].
• INTERPRETATION: Magnesium sulphate halves the risk of eclampsia, and probably reduces the risk of maternal death [2].
• Cellular [ATP] was preserved throughout hypoxia, as assessed using the probe Magnesium Green [3].
• BACKGROUND: Magnesium supplementation may reduce the incidence of arrhythmias, which often occur after cardiac surgery; however, recent findings of the effectiveness of magnesium prophylaxis have yielded discrepant results [4].
• CONCLUSIONS: Magnesium sulfate is well tolerated after acute stroke and has no deleterious hemodynamic effects at this dose [5].

Psychiatry related information on magnesium

• CONCLUSIONS: Magnesium was not effective for the treatment of nocturnal leg cramps [6].
• Evidence is presented indicating that dementias are associated with a relative insufficiency of Magnesium (Mg) in the brain [7].
• CONCLUSIONS: Magnesium administration is safe and improves short-term postoperative neurologic function after cardiac surgery, particularly in preserving short-term memory and cortical control over brainstem functions [8].

High impact information on magnesium

• Letter: Magnesium in heart muscle [9].
• Immune T lymphocyte to tumor cell adhesion. Magnesium sufficient, calcium insufficient [10].
• Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA [11].
• Knock-out of the Magnesium Protoporphyrin IX Methyltransferase Gene in Arabidopsis: EFFECTS ON CHLOROPLAST DEVELOPMENT AND ON CHLOROPLAST-TO-NUCLEUS SIGNALING [12].
• Magnesium ion-dependent activation of the RecA protein involves the C terminus [13].

Chemical compound and disease context of magnesium

• The Magnesium and Neurologic Endpoints Trial was a randomized controlled trial (RCT) done to learn whether or not receiving magnesium sulfate during preterm labor could prevent cerebral palsy [14].
• The effects of oral Magnesium (Mg) pyrrolidone carboxylic acid were evaluated in 20 patients affected by menstrual migraine, in a double-blind, placebo controlled study [15].
• 5. Magnesium depletion and chlorothiazide treatment produce intracellular alkalosis by unknown mechanism(s) [16].

Biological context of magnesium

• Kinetics and Mechanism of Ketone Enolization Mediated by Magnesium Bis(hexamethyldisilazide) [17].
• RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe [18].
• Magnesium ion catalyzed P-N bond hydrolysis in imidazolide-activated nucleotides. Relevance to template-directed synthesis of polynucleotides [19].
• RESULTS: Magnesium was well tolerated, with no significant adverse effects and no change in blood pressure or pulse rate [5].
• DESIGN: Magnesium bioavailability was measured in 10 healthy women with the use of a crossover design [20].

Anatomical context of magnesium

• RESULTS: Magnesium concentrations in erythrocytes, serum (total and ultrafilterable), and urine were significantly lower when dietary magnesium was lower [21].
• Structural dynamics of bacterial ribosomes. V. Magnesium-dependent dissociation of tight couples into subunits: measurements of dissociation constants and exchange rates [22].
• Magnesium ion-dependent contraction of skinned frog muscle fibers in calcium-free solution [23].
• The mgtC Gene of Burkholderia cenocepacia Is Required for Growth under Magnesium Limitation Conditions and Intracellular Survival in Macrophages [24].
• We used Magnesium Green AM to measure Ca(2+) transients in Schaffer collateral presynaptic terminals simultaneously with postsynaptic field potentials (fEPSPs) to investigate the mechanism of neurosteroid enhancement of short-term synaptic facilitation [25].

Associations of magnesium with other chemical compounds

• CONCLUSIONS: Magnesium supplementation prevents blood pressure elevation in DOCA hypertensive rats [26].
• CONCLUSION: Magnesium chloride slows gastric emptying but does not influence lipid digestion [27].
• [Chemical reaction: see text] Magnesium bistrifluoromethanesulfonimide catalyzed the acetylation of phenols, alcohols, and thiols under solvent-free conditions at room temperature and in short times [28].
• CONCLUSIONS: (1) Magnesium sulfate attenuates peroxide-induced vasoconstriction in the human placenta [29].
• RESULTS: Magnesium groups required significantly less propofol [mean (sd) 121.5 (13.3), 102.2 (8.0) and 101.3 (9.7) microg kg(-1) min(-1) respectively] than the control group (140.7 (16.5) microg kg(-1) min(-1)) [30].

Gene context of magnesium

• Magnesium ion requirements for yeast enolase activity [31].
• Active hormonal vitamin D (1,25(OH)(2)D) was lower in the CF group ( P<0.0001), not explained by 25OHD or disease severity, as was serum magnesium ( P<0.0001) [32].
• Magnesium ion does not enhance the ultraviolet inactivation of thymidylate kinase by 5-iodinated nucleoside analogs [33].
• OBJECTIVE: Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults [34].
• Results obtained agreed well with those by an atomic absorption procedure (x): SMAC magnesium - 0.971 x + 0.030 mmol/L (n = 58) [35].

Analytical, diagnostic and therapeutic context of magnesium

• Effect of magnesium on restenosis after percutaneous transluminal coronary angioplasty: a clinical and angiographic evaluation in a randomized patient population. A pilot study. The Ichilov Magnesium Study Group [36].
• 1. Magnesium sulphate was studied for its effects on diarrhoea, fluid secretion, gastrointestinal transit and nitric oxide (NO) synthase activity in rats [37].
• Magnesium ion concentrations at 24 hours were significantly decreased from the preinfusion value of 0.49 +/- 0.01 mmol/L in the control group (0.34 +/- 0.03 mmol/L) but remained within normal ranges in the maintenance group (0.46 +/- 0.02 mmol/L with a pump infusing 72 mg/kg per hour and 0.56 +/- 0.05 mmol/L with a pump infusing 24 mg/kg hour) [38].
• Implications: Magnesium sulfate potentiates morphine analgesia when coadministered intrathecally in normal rats, and in an animal model of mechanical allodynia after a surgical incision [39].
• CONCLUSIONS: Magnesium sulfate tocolysis was not associated with increased neonatal mortality in premature infants [40].

References