Disease relevance of Metamiton

• Disposition kinetic behavior and metabolism studies of metamitron and its metabolite in terms of the parent compound were carried out in black Bengal goats after a single oral administration of a nontoxic oral dose at 30 mg kg(-1) of body weight [1].
• Then the toxicity of four representative herbicides, alloxydim, and sethoxydim (inhibitors of acetyl-coA carboxilase), metamitron (inhibitor of photosynthesis) and clopyralid (inhibitor of respiration), were assayed on the optimal culture conditions for D. primolecta during 96h [2].
• Rapid degradation of the triazinone herbicide metamitron by a Rhodococcus sp. isolated from treated soil [3].

High impact information on Metamiton

• Metamitron was excreted through feces and urine for up to 48 and 72 h, whereas the metabolite was excreted for up to 168 and 144 h, respectively [1].
• The effects of a pesticide mixture (asulam, fluazinam, lambda-cyhalothrin, and metamitron) on aquatic ecosystems were investigated in 20 outdoor aquatic microcosms [4].
• Repeated oral administration of metamitron at 30 mg kg(-1) for 7 days caused induction of the cytochrome P(450) content of liver microsomal pellet of goat, suggesting oxidative deamination of metamitron [5].
• Toxicokinetics, recovery, and metabolism of metamitron in goat [5].
• Maximum concentration of metamitron residue was found in the adrenal gland followed by bile on day 4 of single oral administration [5].

Biological context of Metamiton

• Metamitron (1) does not undergo hydrolysis at pH 1-8 and up to 5 M H(2)SO(4) [6].
• Biotransformation of metamitron by human p450 expressed in transgenic tobacco cell cultures [7].
• In the present investigation, the oxidative metabolism of 14C-labeled metamitron was examined in plant cell cultures of tobacco overexpressing human P450 enzymes CYP1A1 or CYP1A2; special interest was in the aromatic hydroxylation of the herbicide [7].

Gene context of Metamiton

• Additionally, it could be demonstrated that both foreign enzymes (CYP1A1, CYP1A2) also catalyzed the deamination of metamitron [7].

Analytical, diagnostic and therapeutic context of Metamiton

• Metabolism of metamitron in goat following a single oral administration of a nontoxic dose level: a continued study [1].
• To address the question "Is the recently recorded poor control of C. album due to decreased sensitivity to metamitron", greenhouse bioassays were carried out [8].

References