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Gene Review

SLC24A4  -  solute carrier family 24...

Homo sapiens

Synonyms: AI2A5, NCKX4, Na(+)/K(+)/Ca(2+)-exchange protein 4, SHEP6, SLC24A2, ...
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High impact information on SLC24A4

  • NCKX4 transcripts were abundantly expressed in all brain regions, aorta, lung, and thymus, as well as at a lower level in many other tissues [1].
  • The discovery of NCKX4, as far as can be ascertained from the current version of the human genome sequence, completes the mammalian potassium-dependent sodium-calcium exchanger gene family [1].
  • The purpose of the present study was to identify the expression and function of NCKX in arteries. mRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR and Northern blot in both rat mesenteric and aortic smooth muscle [2].
  • NCKX2 is expressed in the brain, in retinal cone photoreceptors and in retinal ganglion cells, while NCKX3 and NCKX4 show a broader expression pattern [3].

Analytical, diagnostic and therapeutic context of SLC24A4


  1. Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4. Li, X.F., Kraev, A.S., Lytton, J. J. Biol. Chem. (2002) [Pubmed]
  2. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. Dong, H., Jiang, Y., Triggle, C.R., Li, X., Lytton, J. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  3. The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond. Schnetkamp, P.P. Pflugers Arch. (2004) [Pubmed]
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