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Gene Review:

orf246 - transcriptional activator

Proteus vulgaris

McGee, D.J. et al., Claret, L. et al., Zhao, H. et al., Poore, C.A. et al., Dattelbaum, J.D. et al., et al.

McGee, Coker, Testerman, Harro, Gibson, Mobley,

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Disease relevance of orf246

The closely related Proteus mirabilis and Enterobacterlaceae plasmid-encoded urease genes are positively regulated by the AraC-like transcriptional activator UreR [1].
In both H. pylori and in an Escherichia coli model of H. pylori urease activity, a high affinity nickel transporter, NixA, is required for optimal urease activity, whereas the urea-dependent UreR positive transcriptional activator governs optimal urease expression in P. mirabilis [2].

High impact information on orf246

The transcriptional activator FlhD2C2 is the master regulator of bacterial flagellum biogenesis and swarming migration, activating the "early" class II promoters of the large flagellar gene hierarchy [3].
UreR, the transcriptional activator of the Proteus mirabilis urease gene cluster, is required for urease activity and virulence in experimental urinary tract infections [4].
While it is recognized that the positive transcriptional activator UreR induces gene expression, the levels of expression of the enzyme during experimental infection are not known [5].
UreR, an AraC-like transcriptional activator, activates transcription of the genes encoding the urease subunits and accessory proteins (ureDABCEFG) in the presence of urea [6].

References

Identification of UreR binding sites in the Enterobacteriaceae plasmid-encoded and Proteus mirabilis urease gene operons. Thomas, V.J., Collins, C.M. Mol. Microbiol. (1999) [Pubmed]
The Helicobacter pylori flbA flagellar biosynthesis and regulatory gene is required for motility and virulence and modulates urease of H. pylori and Proteus mirabilis. McGee, D.J., Coker, C., Testerman, T.L., Harro, J.M., Gibson, S.V., Mobley, H.L. J. Med. Microbiol. (2002) [Pubmed]
Interaction of the atypical prokaryotic transcription activator FlhD2C2 with early promoters of the flagellar gene hierarchy. Claret, L., Hughes, C. J. Mol. Biol. (2002) [Pubmed]
UreR, the transcriptional activator of the Proteus mirabilis urease gene cluster, is required for urease activity and virulence in experimental urinary tract infections. Dattelbaum, J.D., Lockatell, C.V., Johnson, D.E., Mobley, H.L. Infect. Immun. (2003) [Pubmed]
Use of green fluorescent protein to assess urease gene expression by uropathogenic Proteus mirabilis during experimental ascending urinary tract infection. Zhao, H., Thompson, R.B., Lockatell, V., Johnson, D.E., Mobley, H.L. Infect. Immun. (1998) [Pubmed]
Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS. Poore, C.A., Mobley, H.L. Microbiology (Reading, Engl.) (2003) [Pubmed]

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