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Cbfa2t3  -  core-binding factor, runt domain, alpha...

Mus musculus

Synonyms: A630044F12Rik, AI465270, AW229127, Cbfa2t3h, ETO-2, ...
 
 
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High impact information on Cbfa2t3h

 

Biological context of Cbfa2t3h

  • We confirmed the nuclear localization of ETO-2 and demonstrated that domain III and the zinc-finger region are not required for nuclear localization [3].
 

Anatomical context of Cbfa2t3h

 

Associations of Cbfa2t3h with chemical compounds

  • This inhibition of ETO-2 interactions with N-CoR is specific because the MYND domain does not inhibit retinoic acid receptor interactions with N-CoR [2].
 

Other interactions of Cbfa2t3h

  • ETO-2, a new member of the ETO-family of nuclear proteins [3].

References

  1. ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Schuh, A.H., Tipping, A.J., Clark, A.J., Hamlett, I., Guyot, B., Iborra, F.J., Rodriguez, P., Strouboulis, J., Enver, T., Vyas, P., Porcher, C. Mol. Cell. Biol. (2005) [Pubmed]
  2. AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. Ibañez, V., Sharma, A., Buonamici, S., Verma, A., Kalakonda, S., Wang, J., Kadkol, S., Saunthararajah, Y. Cancer Res. (2004) [Pubmed]
  3. ETO-2, a new member of the ETO-family of nuclear proteins. Davis, J.N., Williams, B.J., Herron, J.T., Galiano, F.J., Meyers, S. Oncogene (1999) [Pubmed]
  4. CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Calabi, F., Cilli, V. Genomics (1998) [Pubmed]
 
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