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Gene Review:

STM2584 - hypothetical protein

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Evdokimov, A.G. et al., Coombes, B.K. et al., Haraga, A. et al.

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Disease relevance of gogB

The genetic regulation of gogB in Salmonella is influenced by the transcriptional activator, SsrB, under SPI-2-inducing conditions, but the modular nature of the gogB gene allows for autonomous expression and type III secretion following horizontal gene transfer into a heterologous pathogen [1].
We have investigated the temperate bacteriophage called Gifsy-1 in S.enterica serovar Typhimurium and show here that the product of the gogB gene encoded within this phage shares similarity with proteins from other Gram-negative pathogens [1].
Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit [2].
A similar alpha-helical domain can be identified in virulence-associated leucine-rich repeat proteins produced by Salmonella typhimurium and Shigella flexneri, and in the conceptual translation products of several open reading frames in Y. pestis [2].

High impact information on gogB

In both crystals, four YopM monomers form a hollow cylinder with an inner diameter of 35 A. The domain that targets YopM for translocation into eukaryotic cells adopts a well-ordered, alpha-helical conformation that packs tightly against the proximal leucine-rich repeat module [2].
A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression [3].

References

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage. Coombes, B.K., Wickham, M.E., Brown, N.F., Lemire, S., Bossi, L., Hsiao, W.W., Brinkman, F.S., Finlay, B.B. J. Mol. Biol. (2005) [Pubmed]
Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit. Evdokimov, A.G., Anderson, D.E., Routzahn, K.M., Waugh, D.S. J. Mol. Biol. (2001) [Pubmed]
A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression. Haraga, A., Miller, S.I. Infect. Immun. (2003) [Pubmed]

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