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Gene Review

ompR  -  response regulator in two-component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3392, JW3368, kmt, ompB
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Disease relevance of ompR


High impact information on ompR


Biological context of ompR


Anatomical context of ompR


Associations of ompR with chemical compounds


Regulatory relationships of ompR


Other interactions of ompR

  • The published sequence of the ompR and envZ genes from Salmonella typhimurium is followed by a partial sequence that is highly homologous to pckA from E. coli [19].
  • The promoter sequence of the ompC gene was compared with that of the ompF gene, both of which are controlled by the osmoregulatory operon, ompB [20].
  • Similarly, induction of the dnaK:lacZ and ibp:lacZ fusions was not altered in either rpoS or ompR genetic backgrounds [21].
  • The effect of SAL on ompF expression was independent of the osmolarity of the medium and was epistatic to certain ompB regulatory mutations: the high levels of ompF expression found in envZ3 and ompR472 strains were greatly reduced by growth in SAL [22].
  • An attenuator precedes ecnA and an ompR-sensitive sigmaS promoter governs expression of ecnB [23].

Analytical, diagnostic and therapeutic context of ompR


Biochemical Parameters

  • The binding affinity (Kd) of OmpR and OmpR-P for various pOmpC and pOmpF binding sites are summarized in Head, et al. [27] For example:
    • Binding to the pOmpF composite site F1-F2-F3, the OmpR-P Kd ≈ 15.4 ± 3.5 nM
    • Binding to the pOmpC composite site C1-C2-C3, the OmpR-P Kd ≈ 31.4 ± 8.0 nM





  1. Osmoregulation of gene expression. I. DNA sequence of the ompR gene of the ompB operon of Escherichia coli and characterization of its gene product. Wurtzel, E.T., Chou, M.Y., Inouye, M. J. Biol. Chem. (1982) [Pubmed]
  2. Molecular analysis of the two-component genes, ompR and envZ, in the symbiotic bacterium Xenorhabdus nematophilus. Tabatabai, N., Forst, S. Mol. Microbiol. (1995) [Pubmed]
  3. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12. Laviña, M., Pugsley, A.P., Moreno, F. J. Gen. Microbiol. (1986) [Pubmed]
  4. Cloning and characterisation of a novel ompB operon from Vibrio cholerae 569B. Tow, L.A., Coyne, V.E. Biochim. Biophys. Acta (1999) [Pubmed]
  5. Deduced polypeptides encoded by the Bacillus subtilis sacU locus share homology with two-component sensor-regulator systems. Kunst, F., Debarbouille, M., Msadek, T., Young, M., Mauel, C., Karamata, D., Klier, A., Rapoport, G., Dedonder, R. J. Bacteriol. (1988) [Pubmed]
  6. Interaction of OmpR, a positive regulator, with the osmoregulated ompC and ompF genes of Escherichia coli. Studies with wild-type and mutant OmpR proteins. Mizuno, T., Kato, M., Jo, Y.L., Mizushima, S. J. Biol. Chem. (1988) [Pubmed]
  7. Properties of Escherichia coli mutants lacking membrane-derived oligosaccharides. Fiedler, W., Rotering, H. J. Biol. Chem. (1988) [Pubmed]
  8. Localization and membrane topology of EnvZ, a protein involved in osmoregulation of OmpF and OmpC in Escherichia coli. Forst, S., Comeau, D., Norioka, S., Inouye, M. J. Biol. Chem. (1987) [Pubmed]
  9. Purification and characterization of the OmpR protein, a positive regulator involved in osmoregulatory expression of the ompF and ompC genes in Escherichia coli. Jo, Y.L., Nara, F., Ichihara, S., Mizuno, T., Mizushima, S. J. Biol. Chem. (1986) [Pubmed]
  10. Structure and expression of the ompB operon, the regulatory locus for the outer membrane porin regulon in Salmonella typhimurium LT-2. Liljeström, P., Laamanen, I., Palva, E.T. J. Mol. Biol. (1988) [Pubmed]
  11. Isolation and characterization of delta ompB strains of Escherichia coli by a general method based on gene fusions. Garrett, S., Taylor, R.K., Silhavy, T.J., Berman, M.L. J. Bacteriol. (1985) [Pubmed]
  12. Molecular analysis of mutant ompR genes exhibiting different phenotypes as to osmoregulation of the ompF and ompC genes of Escherichia coli. Nara, F., Matsuyama, S., Mizuno, T., Mizushima, S. Mol. Gen. Genet. (1986) [Pubmed]
  13. The major outer membrane protein rOmpB of spotted fever group rickettsiae functions in the rickettsial adherence to and invasion of Vero cells. Uchiyama, T., Kawano, H., Kusuhara, Y. Microbes Infect. (2006) [Pubmed]
  14. Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR. Shin, S., Park, C. J. Bacteriol. (1995) [Pubmed]
  15. The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli. Mortimer, P.G., Piddock, L.J. J. Antimicrob. Chemother. (1993) [Pubmed]
  16. Positive and negative control of ompB transcription in Escherichia coli by cyclic AMP and the cyclic AMP receptor protein. Huang, L., Tsui, P., Freundlich, M. J. Bacteriol. (1992) [Pubmed]
  17. Positive control of transcription initiation in Escherichia coli. A base substitution at the Pribnow box renders ompF expression independent of a positive regulator. Dairi, T., Inokuchi, K., Mizuno, T., Mizushima, S. J. Mol. Biol. (1985) [Pubmed]
  18. Stereospecific positioning of the cis-acting sequence with respect to the canonical promoter is required for activation of the ompC gene by a positive regulator, OmpR, in Escherichia coli. Maeda, S., Ozawa, Y., Mizuno, T., Mizushima, S. J. Mol. Biol. (1988) [Pubmed]
  19. Sequence of the pckA gene of Escherichia coli K-12: relevance to genetic and allosteric regulation and homology of E. coli phosphoenolpyruvate carboxykinase with the enzymes from Trypanosoma brucei and Saccharomyces cerevisiae. Medina, V., Pontarollo, R., Glaeske, D., Tabel, H., Goldie, H. J. Bacteriol. (1990) [Pubmed]
  20. A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene. Mizuno, T., Chou, M.Y., Inouye, M. J. Biol. Chem. (1983) [Pubmed]
  21. Hyperosmotic shock induces the sigma32 and sigmaE stress regulons of Escherichia coli. Bianchi, A.A., Baneyx, F. Mol. Microbiol. (1999) [Pubmed]
  22. Regulation of ompF porin expression by salicylate in Escherichia coli. Rosner, J.L., Chai, T.J., Foulds, J. J. Bacteriol. (1991) [Pubmed]
  23. The entericidin locus of Escherichia coli and its implications for programmed bacterial cell death. Bishop, R.E., Leskiw, B.K., Hodges, R.S., Kay, C.M., Weiner, J.H. J. Mol. Biol. (1998) [Pubmed]
  24. OmpR-dependent and OmpR-independent responses of Escherichia coli to sublethal attack by the neutrophil bactericidal/permeability increasing protein. Prohinar, P., Forst, S.A., Reed, D., Mandic-Mulec, I., Weiss, J. Mol. Microbiol. (2002) [Pubmed]
  25. Multicellular and aggregative behaviour of Salmonella typhimurium strains is controlled by mutations in the agfD promoter. Römling, U., Sierralta, W.D., Eriksson, K., Normark, S. Mol. Microbiol. (1998) [Pubmed]
  26. Adherence to and invasion of Vero cells by recombinant Escherichia coli expressing the outer membrane protein rOmpB of Rickettsia japonica. Uchiyama, T. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  27. Relative binding affinities of OmpR and OmpR-phosphate at the ompF and ompC regulatory sites. Head, C.G., Tardy, A., Kenney, L.J. J. Mol. Biol. (1998) [Pubmed]
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